Exosome processing and characterization approaches for research and technology development

JJ Lai, ZL Chau, SY Chen, JJ Hill… - Advanced …, 2022 - Wiley Online Library
Exosomes are extracellular vesicles that share components of their parent cells and are
attractive in biotechnology and biomedical research as potential disease biomarkers as well …

STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response

M Sadrkhanloo, M Entezari, S Orouei, M Ghollasi… - Pharmacological …, 2022 - Elsevier
Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis of
tumor cells and their spread to various organs and tissues of body, providing undesirable …

Biodistribution of exosomes and engineering strategies for targeted delivery of therapeutic exosomes

H Choi, Y Choi, HY Yim, A Mirzaaghasi, JK Yoo… - Tissue engineering and …, 2021 - Springer
Exosomes are cell-secreted nano-sized vesicles which deliver diverse biological molecules
for intercellular communication. Due to their therapeutic potential, exosomes have been …

Biological, diagnostic and therapeutic implications of exosomes in glioma

CL Davidson, R Vengoji, M Jain, SK Batra, N Shonka - Cancer letters, 2024 - Elsevier
Despite therapeutic advances, overall survival in glioblastoma is dismal. To optimize
progress, a more detailed understanding of glioma's molecular, cellular, and intercellular …

Patient-derived exosomes facilitate therapeutic targeting of oncogenic MET in advanced gastric cancer

S Hyung, J Ko, YJ Heo, SM Blum, ST Kim, SH Park… - Science …, 2023 - science.org
Gastric cancer (GC) with peritoneal metastases and malignant ascites continues to have
poor prognosis. Exosomes mediate intercellular communication during cancer progression …

Exosomes from different cells: Characteristics, modifications, and therapeutic applications

M Li, S Li, C Du, Y Zhang, Y Li, L Chu, X Han… - European Journal of …, 2020 - Elsevier
Exosomes are cystic vesicles secreted by living cells with a phospholipid bilayer membrane.
Importantly, these vesicles could serve to carry lipids, proteins, genetic materials, and …

The emerging role of exosomes as novel therapeutics: Biology, technologies, clinical applications, and the next

Y Song, Y Kim, S Ha, S Sheller‐Miller… - American Journal of …, 2021 - Wiley Online Library
The extracellular vesicles (EVs) research area has grown rapidly because of their pivotal
roles in intercellular communications and maintaining homeostasis of individual organism …

Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases

GG Shetgaonkar, SM Marques, CEM DCruz… - Drug Delivery and …, 2022 - Springer
Exosomes are extracellular vesicles with the diameter ranging from 50 to 100 nm and are
found in different body fluids such as blood, cerebrospinal fluid (CSF), urine and saliva. Like …

Hypoxic regulation of extracellular vesicles: Implications for cancer therapy

S Yoo, S Choi, I Kim, IS Kim - Journal of Controlled Release, 2023 - Elsevier
Extracellular vesicles (EVs) play a pivotal role in intercellular communication and have been
implicated in cancer progression. Hypoxia, a pervasive hallmark of cancer, is known to …

[HTML][HTML] The right Timing, right combination, right sequence, and right delivery for Cancer immunotherapy

M Kwon, H Jung, GH Nam, IS Kim - Journal of Controlled Release, 2021 - Elsevier
Cancer immunotherapy (CI) represented by immune checkpoint inhibitors (ICIs) presents a
new paradigm for cancer treatment. However, the types of cancer that attain a therapeutic …