Is localized acquired resistance the mechanism for effector-triggered disease resistance in plants?

P Jacob, J Hige, JL Dangl - Nature Plants, 2023 - nature.com
Plant nucleotide-binding leucine-rich repeat receptors (NLRs) are intracellular immune
receptors that are activated by their direct or indirect interactions with virulence effectors …

[HTML][HTML] TIR-domain enzymatic activities at the heart of plant immunity

F Locci, J Wang, JE Parker - Current Opinion in Plant Biology, 2023 - Elsevier
Abstract Toll/interleukin-1/resistance (TIR) domain proteins contribute to innate immunity in
all cellular kingdoms. TIR modules are activated by self-association and in plants, mammals …

Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling

MK Manik, Y Shi, S Li, MA Zaydman, N Damaraju… - Science, 2022 - science.org
Cyclic adenosine diphosphate (ADP)–ribose (cADPR) isomers are signaling molecules
produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide …

Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products

AM Bayless, S Chen, SC Ogden, X Xu, JD Sidda… - Science …, 2023 - science.org
Toll/interleukin-1 receptor (TIR) domain proteins function in cell death and immunity. In
plants and bacteria, TIR domains are often enzymes that produce isomers of cyclic …

Activation mechanism of a short argonaute-TIR prokaryotic immune system

D Ni, X Lu, H Stahlberg, B Ekundayo - Science Advances, 2023 - science.org
Short prokaryotic argonaute (pAgo) and toll/interleukin-1 receptor/resistance protein (TIR)–
analog of PAZ (APAZ) form a heterodimeric SPARTA complex that provides immunity to its …

Activation of a helper NLR by plant and bacterial TIR immune signaling

H Yu, W Xu, S Chen, X Wu, W Rao, X Liu, X Xu, J Chen… - Science, 2024 - science.org
Plant intracellular nucleotide-binding leucine-rich repeat (NLR) receptors with an N-terminal
Toll/interleukin-1 receptor (TIR) domain sense pathogen effectors to initiate immune …

Plasma membrane association and resistosome formation of plant helper immune receptors

Z Wang, X Liu, J Yu, S Yin, W Cai… - Proceedings of the …, 2023 - National Acad Sciences
Intracellular plant immune receptors, termed NLRs (Nucleotide-binding Leucine-rich repeat
Receptors), confer effector-triggered immunity. Sensor NLRs are responsible for pathogen …

Broader functions of TIR domains in Arabidopsis immunity

P Jacob, J Hige, L Song, A Bayless… - Proceedings of the …, 2023 - National Acad Sciences
TIR domains are NAD-degrading enzymes that function during immune signaling in
prokaryotes, plants, and animals. In plants, most TIR domains are incorporated into …

The NLR immune receptor ADR1 and lipase-like proteins EDS1 and PAD4 mediate stomatal immunity in Nicotiana benthamiana and Arabidopsis

H Wang, S Song, S Gao, Q Yu, H Zhang, X Cui… - The Plant …, 2024 - academic.oup.com
In the presence of pathogenic bacteria, plants close their stomata to prevent pathogen entry.
Intracellular nucleotide-binding leucine-rich repeat (NLR) immune receptors recognize …

The immune modules conserved across the tree of life: Towards a definition of ancestral immunity

A Bernheim, J Cury, EZ Poirier - Plos Biology, 2024 - journals.plos.org
Immune defence mechanisms exist across the tree of life in such diversity that prokaryotic
antiviral responses have historically been considered unrelated to eukaryotic immunity …