Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant
cells are capable of esca** host immune surveillance by inactivating cytotoxic lymphoid …

Generally, the high diversity of protein properties necessitates the development of unique
nanoparticle bio-conjugation methods, optimized for each different protein. Here we …

Prion infections cause conformational changes of the cellular prion protein (PrPC) and lead
to progressive neurological impairment. Here we show that toxic, prion-mimetic ligands …

High mobility group box 1 (HMGB1) is a non-histone protein localised in the cell nucleus,
where it interacts with DNA and promotes nuclear transcription events. HMGB1 levels are …

We introduce the concept of circular dichroism (CD) imaging CD i, which is made possible
by the use of the highly collimated light beam of synchrotron radiation (SR) only available at …

Hypothesis We developed a geometrical model to determine the theoretical maximum
number of proteins that can pack as a monolayer surrounding a spherical nanoparticle. We …

The lipid bilayer is a dynamic environment that consists of a mixture of lipids with different
properties that regulate the function of membrane proteins; these lipids are either annular …

Bleomycin is a glycopeptide congeners' family of antitumor antibiotics employed for the
treatment of several types of tumors such as squamous cell carcinomas and malignant …

Virulence gene expression in the human pathogen, S. aureus is regulated by the agr
(accessory gene regulator) quorum sensing (QS) system which is conserved in diverse …

While the molecular details by which Hsp90 interacts with Sgt1 and Rar1 were previously
described the exact stoichiometric complex that is formed remains elusive. Several …