Systems approaches have long been used in pharmacology to understand drug action at
the organ and organismal levels. The application of computational and experimental …

The gut microbiome is crucial for nutrient metabolism, immune regulation, and intestinal
homeostasis with changes in its composition linked to complex diseases like inflammatory …

Genomics, epigenomics, transcriptomics, proteomics and metabolomics efforts rapidly
generate a plethora of data on the activity and levels of biomolecules within mammalian …

Background System-wide profiling of genes and proteins in mammalian cells produce lists of
differentially expressed genes/proteins that need to be further analyzed for their collective …

IntAct (freely available at http://www. ebi. ac. uk/intact) is an open-source, open data
molecular interaction database populated by data either curated from the literature or from …

Human immunodeficiency virus (HIV) has a small genome and therefore relies heavily on
the host cellular machinery to replicate. Identifying which host proteins and complexes come …

ABSTRACT MINT (http://mint. bio. uniroma2. it/mint) is a public repository for molecular
interactions reported in peer-reviewed journals. Since its last report, MINT has grown …

Abstract VirHostNet release 2.0 (http://virhostnet. prabi. fr) is a knowledgebase dedicated to
the network-based exploration of virus–host protein–protein interactions. Since the previous …

Abstract Human Immunodeficiency Virus (HIV) relies on host molecular machinery for
replication. Systematic attempts to genetically or biochemically define these host factors …

Viral infections often cause diseases by perturbing several cellular processes in the infected
host. Viral proteins target host proteins and either form new complexes or modulate the …