Antibiotic resistance is mediated through several distinct mechanisms, most of which are
relatively well understood and the clinical importance of which has long been recognized …

Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …

The upsurge of multiple drug resistance (MDR) bacteria substantially diminishes the
effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure. The …

Target protection proteins confer resistance to the host organism by directly binding to the
antibiotic target. One class of such proteins are the antibiotic resistance (ARE) ATP-binding …

In the present chapter, the synopsis of active botanicals and phytochemicals of the flora of
Africa against drug-sensitive and drug-resistant strains of bacteria of the Enterobacteriaceae …

The acquisition process of antibiotic resistance in an otherwise susceptible organism is
shaped by the ecology of the species. Unlike other relevant human pathogens, Listeria …

HflX is a ubiquitous bacterial GTPase that splits and recycles stressed ribosomes. In addition
to HflX, Listeria monocytogenes contains a second HflX homolog, HflXr. Unlike HflX, HflXr …

Translation and ribosome biogenesis in mitochondria require auxiliary factors that ensure
rapid and accurate synthesis of mitochondrial proteins. Defects in translation are associated …

During stress conditions such as heat shock and antibiotic exposure, ribosomes stall on
messenger RNAs, leading to inhibition of protein synthesis. To remobilize ribosomes …

The evolution of antimicrobial resistance (AMR) poses a persistent threat to global public
health. Sequencing efforts have already yielded genome sequences for thousands of …