Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune
responses in cancer and other pathological conditions. In recent years, ample evidence …
responses in cancer and other pathological conditions. In recent years, ample evidence …
The nature of myeloid-derived suppressor cells in the tumor microenvironment
V Kumar, S Patel, E Tcyganov, DI Gabrilovich - Trends in immunology, 2016 - cell.com
Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor
microenvironment. The main feature of these cells is their potent immune suppressive …
microenvironment. The main feature of these cells is their potent immune suppressive …
Coordinated regulation of myeloid cells by tumours
DI Gabrilovich, S Ostrand-Rosenberg… - Nature Reviews …, 2012 - nature.com
Myeloid cells are the most abundant nucleated haematopoietic cells in the human body and
are a collection of distinct cell populations with many diverse functions. The three groups of …
are a collection of distinct cell populations with many diverse functions. The three groups of …
Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics
H Alshetaiwi, N Pervolarakis, LL McIntyre, D Ma… - Science …, 2020 - science.org
Myeloid-derived suppressor cells (MDSCs) are innate immune cells that acquire the
capacity to suppress adaptive immune responses during cancer. It remains elusive how …
capacity to suppress adaptive immune responses during cancer. It remains elusive how …
Advances in graft-versus-host disease biology and therapy
Allogeneic haematopoietic stem cell transplantation is used to treat a variety of disorders,
but its efficacy is limited by the occurrence of graft-versus-host disease (GVHD). The past …
but its efficacy is limited by the occurrence of graft-versus-host disease (GVHD). The past …
Recent advances in the mechanisms and treatment of immune thrombocytopenia
Primary immune thrombocytopenia is an autoimmune disease associated with a reduced
peripheral blood platelet count. The phenotype is variable with some patients suffering no …
peripheral blood platelet count. The phenotype is variable with some patients suffering no …
Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function
T Condamine, DI Gabrilovich - Trends in immunology, 2011 - cell.com
Myeloid-derived suppressor cells (MDSCs) are one of the main cell populations responsible
for regulating immune responses. MDSCs accumulate during tumor progression …
for regulating immune responses. MDSCs accumulate during tumor progression …
Myeloid-derived suppressor cells: critical cells driving immune suppression in the tumor microenvironment
KH Parker, DW Beury, S Ostrand-Rosenberg - Advances in cancer …, 2015 - Elsevier
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that suppress innate and adaptive immunity. MDSCs are present in many …
myeloid cells that suppress innate and adaptive immunity. MDSCs are present in many …
Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies
F Hossain, AA Al-Khami, D Wyczechowska… - Cancer immunology …, 2015 - AACR
Myeloid-derived suppressor cells (MDSC) promote tumor growth by inhibiting T-cell
immunity and promoting malignant cell proliferation and migration. The therapeutic potential …
immunity and promoting malignant cell proliferation and migration. The therapeutic potential …
Ablative tumor radiation can change the tumor immune cell microenvironment to induce durable complete remissions
A Filatenkov, J Baker, AMS Mueller, J Kenkel… - Clinical Cancer …, 2015 - AACR
Purpose: The goals of the study were to elucidate the immune mechanisms that contribute to
desirable complete remissions of murine colon tumors treated with single radiation dose of …
desirable complete remissions of murine colon tumors treated with single radiation dose of …