Role of Bruton's tyrosine kinase in B cells and malignancies
Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …
signaling that is critical for proliferation and survival of leukemic cells in many B cell …
Memory B cells
T Kurosaki, K Kometani, W Ise - Nature Reviews Immunology, 2015 - nature.com
The immune system can remember a previously experienced pathogen and can evoke an
enhanced response to reinfection that depends on memory lymphocyte populations. Recent …
enhanced response to reinfection that depends on memory lymphocyte populations. Recent …
Molecular programming of B cell memory
M McHeyzer-Williams, S Okitsu, N Wang… - Nature Reviews …, 2012 - nature.com
The development of high-affinity B cell memory is regulated through three separable
phases, each involving antigen recognition by specific B cells and cognate T helper cells …
phases, each involving antigen recognition by specific B cells and cognate T helper cells …
Pathogenesis of human B cell lymphomas
The mechanisms that drive normal B cell differentiation and activation are frequently
subverted by B cell lymphomas for their unlimited growth and survival. B cells are …
subverted by B cell lymphomas for their unlimited growth and survival. B cells are …
Human memory B cells
M Seifert, R Küppers - Leukemia, 2016 - nature.com
A key feature of the adaptive immune system is the generation of memory B and T cells and
long-lived plasma cells, providing protective immunity against recurring infectious agents …
long-lived plasma cells, providing protective immunity against recurring infectious agents …
Epigenetic recording of stimulation history reveals BLIMP1–BACH2 balance in determining memory B cell fate upon recall challenge
W Shao, Y Wang, Q Fang, W Shi, H Qi - Nature Immunology, 2024 - nature.com
Memory B cells (MBCs) differentiate into plasma cells (PCs) or germinal centers (GCs) upon
antigen recall. How this decision is programmed is not understood. We found that the …
antigen recall. How this decision is programmed is not understood. We found that the …
Memory B cells of mice and humans
F Weisel, M Shlomchik - Annual review of immunology, 2017 - annualreviews.org
We comprehensively review memory B cells (MBCs), covering the definition of MBCs and
their identities and subsets, how MBCs are generated, where they are localized, how they …
their identities and subsets, how MBCs are generated, where they are localized, how they …
Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow
The longevity of plasma cells is dependent on their ability to access and reside in so-called
niches that are predominantly located in the bone marrow. Here, by employing a traceable …
niches that are predominantly located in the bone marrow. Here, by employing a traceable …
B‐cell receptor signalling and its crosstalk with other pathways in normal and malignant cells
The physiology of B cells is intimately connected with the function of their B‐cell receptor
(BCR). B‐cell lymphomas frequently (dys) regulate BCR signalling and thus take advantage …
(BCR). B‐cell lymphomas frequently (dys) regulate BCR signalling and thus take advantage …
Affinity-restricted memory B cells dominate recall responses to heterologous flaviviruses
Memory B cells (MBCs) can respond to heterologous antigens either by molding new
specificities through secondary germinal centers (GCs) or by selecting preexisting clones …
specificities through secondary germinal centers (GCs) or by selecting preexisting clones …