[HTML][HTML] Phage therapy: From biological mechanisms to future directions

SA Strathdee, GF Hatfull, VK Mutalik, RT Schooley - Cell, 2023 - cell.com
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research,
the natural predators of bacteria discovered over 100 years ago. In order to use phages …

Resistance of gram-negative bacteria to current antibacterial agents and approaches to resolve it

Z Breijyeh, B Jubeh, R Karaman - Molecules, 2020 - mdpi.com
Antimicrobial resistance represents an enormous global health crisis and one of the most
serious threats humans face today. Some bacterial strains have acquired resistance to …

Phage therapy for antibiotic-resistant bacterial infections

GF Hatfull, RM Dedrick… - Annual Review of …, 2022 - annualreviews.org
Antibiotic resistance in bacterial pathogens presents a substantial threat to the control of
infectious diseases. Development of new classes of antibiotics has slowed in recent years …

Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review

S Uyttebroek, B Chen, J Onsea… - The Lancet Infectious …, 2022 - thelancet.com
According to the latest reports from WHO, the incidence of antibiotic-resistant bacterial
infections is increasing worldwide, resulting in increased morbidity and mortality and a rising …

[HTML][HTML] Phage therapy: a renewed approach to combat antibiotic-resistant bacteria

KE Kortright, BK Chan, JL Koff, PE Turner - Cell host & microbe, 2019 - cell.com
Phage therapy, long overshadowed by chemical antibiotics, is garnering renewed interest in
Western medicine. This stems from the rise in frequency of multi-drug-resistant bacterial …

Development and use of personalized bacteriophage-based therapeutic cocktails to treat a patient with a disseminated resistant Acinetobacter baumannii infection

RT Schooley, B Biswas, JJ Gill… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Widespread antibiotic use in clinical medicine and the livestock industry has contributed to
the global spread of multidrug-resistant (MDR) bacterial pathogens, including Acinetobacter …

Phage Therapy of Mycobacterium Infections: Compassionate Use of Phages in 20 Patients With Drug-Resistant Mycobacterial Disease

RM Dedrick, BE Smith, M Cristinziano… - Clinical infectious …, 2023 - academic.oup.com
Abstract Background Nontuberculous Mycobacterium infections, particularly Mycobacterium
abscessus, are increasingly common among patients with cystic fibrosis and chronic …

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

YI Duan, C Llorente, S Lang, K Brandl, H Chu, L Jiang… - Nature, 2019 - nature.com
Chronic liver disease due to alcohol-use disorder contributes markedly to the global burden
of disease and mortality,–. Alcoholic hepatitis is a severe and life-threatening form of alcohol …

The safety and toxicity of phage therapy: a review of animal and clinical studies

D Liu, JD Van Belleghem, CR de Vries, E Burgener… - Viruses, 2021 - mdpi.com
Increasing rates of infection by antibiotic resistant bacteria have led to a resurgence of
interest in bacteriophage (phage) therapy. Several phage therapy studies in animals and …

[HTML][HTML] Advantages and limitations of bacteriophages for the treatment of bacterial infections

N Principi, E Silvestri, S Esposito - Frontiers in pharmacology, 2019 - frontiersin.org
Bacteriophages (BPs) are viruses that can infect and kill bacteria without any negative effect
on human or animal cells. For this reason, it is supposed that they can be used, alone or in …