Phage therapy: From biological mechanisms to future directions

SA Strathdee, GF Hatfull, VK Mutalik, RT Schooley - Cell, 2023 - cell.com
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research,
the natural predators of bacteria discovered over 100 years ago. In order to use phages …

Alternative therapeutic strategies to treat antibiotic-resistant pathogens

CR MacNair, ST Rutherford, MW Tan - Nature Reviews Microbiology, 2024 - nature.com
Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …

Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice

YE Gencay, D Jasinskytė, C Robert, S Semsey… - Nature …, 2024 - nature.com
Antibiotic treatments have detrimental effects on the microbiome and lead to antibiotic
resistance. To develop a phage therapy against a diverse range of clinically relevant …

Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review

S Uyttebroek, B Chen, J Onsea… - The Lancet Infectious …, 2022 - thelancet.com
According to the latest reports from WHO, the incidence of antibiotic-resistant bacterial
infections is increasing worldwide, resulting in increased morbidity and mortality and a rising …

Phage Therapy of Mycobacterium Infections: Compassionate Use of Phages in 20 Patients With Drug-Resistant Mycobacterial Disease

RM Dedrick, BE Smith, M Cristinziano… - Clinical infectious …, 2023 - academic.oup.com
Abstract Background Nontuberculous Mycobacterium infections, particularly Mycobacterium
abscessus, are increasingly common among patients with cystic fibrosis and chronic …

Phage therapy for antibiotic-resistant bacterial infections

GF Hatfull, RM Dedrick… - Annual review of medicine, 2022 - annualreviews.org
Antibiotic resistance in bacterial pathogens presents a substantial threat to the control of
infectious diseases. Development of new classes of antibiotics has slowed in recent years …

Mutualistic interplay between bacteriophages and bacteria in the human gut

AN Shkoporov, CJ Turkington, C Hill - Nature Reviews Microbiology, 2022 - nature.com
Bacteriophages (phages) are often described as obligate predators of their bacterial hosts,
and phage predation is one of the leading forces controlling the density and distribution of …

Regulations of phage therapy across the world

Q Yang, S Le, T Zhu, N Wu - Frontiers in microbiology, 2023 - frontiersin.org
Phage therapy, a century-long treatment targeting bacterial infection, was widely abandoned
after the clinical availability of antibiotics in the mid-20th century. However, the crisis of …

Resistance of gram-negative bacteria to current antibacterial agents and approaches to resolve it

Z Breijyeh, B Jubeh, R Karaman - Molecules, 2020 - mdpi.com
Antimicrobial resistance represents an enormous global health crisis and one of the most
serious threats humans face today. Some bacterial strains have acquired resistance to …

[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system

TCA Hitch, LJ Hall, SK Walsh, GE Leventhal, E Slack… - Mucosal …, 2022 - Elsevier
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …