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Phage therapy: From biological mechanisms to future directions
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research,
the natural predators of bacteria discovered over 100 years ago. In order to use phages …
the natural predators of bacteria discovered over 100 years ago. In order to use phages …
Alternative therapeutic strategies to treat antibiotic-resistant pathogens
Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …
ineffective, thus posing a threat to human health. The discovery of novel classes of …
Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice
Antibiotic treatments have detrimental effects on the microbiome and lead to antibiotic
resistance. To develop a phage therapy against a diverse range of clinically relevant …
resistance. To develop a phage therapy against a diverse range of clinically relevant …
Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review
S Uyttebroek, B Chen, J Onsea… - The Lancet Infectious …, 2022 - thelancet.com
According to the latest reports from WHO, the incidence of antibiotic-resistant bacterial
infections is increasing worldwide, resulting in increased morbidity and mortality and a rising …
infections is increasing worldwide, resulting in increased morbidity and mortality and a rising …
Phage Therapy of Mycobacterium Infections: Compassionate Use of Phages in 20 Patients With Drug-Resistant Mycobacterial Disease
RM Dedrick, BE Smith, M Cristinziano… - Clinical infectious …, 2023 - academic.oup.com
Abstract Background Nontuberculous Mycobacterium infections, particularly Mycobacterium
abscessus, are increasingly common among patients with cystic fibrosis and chronic …
abscessus, are increasingly common among patients with cystic fibrosis and chronic …
Phage therapy for antibiotic-resistant bacterial infections
GF Hatfull, RM Dedrick… - Annual review of medicine, 2022 - annualreviews.org
Antibiotic resistance in bacterial pathogens presents a substantial threat to the control of
infectious diseases. Development of new classes of antibiotics has slowed in recent years …
infectious diseases. Development of new classes of antibiotics has slowed in recent years …
Mutualistic interplay between bacteriophages and bacteria in the human gut
Bacteriophages (phages) are often described as obligate predators of their bacterial hosts,
and phage predation is one of the leading forces controlling the density and distribution of …
and phage predation is one of the leading forces controlling the density and distribution of …
Regulations of phage therapy across the world
Phage therapy, a century-long treatment targeting bacterial infection, was widely abandoned
after the clinical availability of antibiotics in the mid-20th century. However, the crisis of …
after the clinical availability of antibiotics in the mid-20th century. However, the crisis of …
Resistance of gram-negative bacteria to current antibacterial agents and approaches to resolve it
Z Breijyeh, B Jubeh, R Karaman - Molecules, 2020 - mdpi.com
Antimicrobial resistance represents an enormous global health crisis and one of the most
serious threats humans face today. Some bacterial strains have acquired resistance to …
serious threats humans face today. Some bacterial strains have acquired resistance to …
[HTML][HTML] Microbiome-based interventions to modulate gut ecology and the immune system
The gut microbiome lies at the intersection between the environment and the host, with the
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …
ability to modify host responses to disease-relevant exposures and stimuli. This is evident in …