Transforming growth factor–β1 (TGF-β1) is inextricably linked to regulatory T cell (Treg)
biology. However, precisely untangling the role for TGF-β1 in Treg differentiation and …

Efficient scanning of tissue that T cells encounter during their migratory life is pivotal to
protective adaptive immunity. In fact, T cells can detect even a single antigenic peptide/MHC …

Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical
and immunological phenotypes. By applying a multiomics approach to a large group of RAG …

The interface between the cellular actin network and diverse forms of integrin-mediated cell
adhesions displays a unique capacity to serve as accurate chemical and mechanical …

Background: Methotrexate (MTX) is one of the most extensively used drugs in the treatment
of moderate-to-severe psoriasis (PS). However, it frequently must be suspended owing to …

CD4+ T cells play a crucial role in adaptive immune responses and have been implicated in
the pathogenesis of autoimmune diseases (ADs). Despite numerous studies, the molecular …

Type 2 innate lymphoid cells (ILC2s) have emerged as key regulators of the immune
response in renal inflammatory diseases such as lupus nephritis. However, the mechanisms …

Hair growth and regeneration represents a remarkable example of stem cell function.
Recent progress emphasizes the micro-and macro-environment that controls the …

Dermal regulatory T cells (Tregs) are essential for maintenance of skin homeostasis and
control of skin inflammatory responses. In mice, Tregs in the skin are characterized by high …

Skin tissue-resident memory T (Trm) cells are produced by antigenic stimulation and remain
in the skin for a long time without entering the peripheral circulation. In the healthy state Trm …