The concept of 'BRCAness' defines the pathogenesis and vulnerability of multiple cancers.
The canonical definition of BRCAness is a defect in homologous recombination repair …

The tumor microenvironment (TME) is a dynamic and complex matter shaped by
heterogenous cancer and cancer‐associated cells present at the tumor site. Hyaluronan …

Breast cancer risk for carriers of BRCA1 pathological variants is modified by genetic factors.
Genetic variation in HMMR may contribute to this effect. However, the impact of risk …

Hyaluronan is an extracellular matrix component that absorbs water in tissues and engages
cell surface receptors, like Cluster of Differentiation 44 (CD44), to promote cellular growth …

Breast cancer is the third most common type of cancer diagnosed. Cell cycle is a complex
but highly organized and controlled process, in which normal cells sense mitogenic growth …

As the most common subtype of lung cancer, lung adenocarcinoma (LUAD) is the frequently
occurred cancers in human. Therefore, thorough investigation is necessary for …

Germline pathogenic mutations in BReast CAncer (BRCA1) genes are thought to drive
normal fallopian tube epithelial (FTE) cell transformation to high-grade serous ovarian …

The functional complexity of higher organisms is not easily accounted for by the size of their
genomes. Rather, complexity appears to be generated by transcriptional, translational, and …

Receptor for hyaluronic acid-mediated motility (RHAMM) is a cell surface receptor for
hyaluronic acid that is critical for cell migration and a cell cycle protein involved in …

Chemotherapy is one of the vital treatments for gastric cancer (GC) patients, especially those
suffering advanced stages. Chemoresistance results in tumor relapse, leading to poor …