CMV is an ancient herpesvirus that has co-evolved with its host over millions of years. The
236 kbp genome encodes at least 165 genes, four non-coding RNAs and 14 miRNAs. Of the …

Viruses manipulate cell biology to utilize monocytes/macrophages as vessels for
dissemination, long-term persistence within tissues and virus replication. Viruses enter cells …

Macrophages are cells that mediate both innate and adaptive immunity reactions, playing a
major role in both physiological and pathological processes. Systemic SARS-CoV-2 …

Latent herpes virus reactivation has been demonstrated in astronauts during shuttle (10–16
days) and International Space Station (≥ 180 days) flights. Following reactivation, viruses …

The human cytomegalovirus (HCMV), whose genome is 235±1.9 kbp long, is a common
herpesvirus. However, the functions of many of its genes are still unknown. HCMV is closely …

The establishment of human cytomegalovirus (HCMV) latency and persistence relies on the
successful infection of hematopoietic cells, which serve as sites of viral persistence and …

Human cytomegalovirus (HCMV) causes a lifelong infection through establishment of
latency. Although reactivation from latency can cause life-threatening disease, our molecular …

Human cytomegalovirus (HCMV) is a ubiquitous herpesviral pathogen that results in life-
long infection. HCMV maintains a latent or quiescent infection in hematopoietic cells, which …

Background Cytomegalovirus (CMV) is a highly prevalent herpesvirus, which maintains
lifelong latency and places a significant burden on host immunity. Infection is associated …

Viral dissemination is a key mechanism responsible for persistence and disease following
human cytomegalovirus (HCMV) infection. Monocytes play a pivotal role in viral …