The Biosurfactant β-Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers

R Geisler, C Dargel, T Hellweg - Molecules, 2019 - mdpi.com
This review discusses recent progress in physicochemical understanding of the action of the
saponin β-aescin (also called β-escin), the biologically active component in the seeds of the …

Recent advances in biosurfactant-based association colloids—self-assembly in water

T Hellweg, T Sottmann, J Oberdisse - Frontiers in Soft Matter, 2023 - frontiersin.org
Recent studies of self-assembly in binary systems of bio-surfactants, either of microbial
origin or saponins extracted from plants, are reviewed. Saponins in water reported in the first …

[HTML][HTML] Self-assembly in escin-nonionic surfactant mixtures: From micelles to vesicles

IM Tucker, A Burley, RE Petkova, SL Hosking… - Journal of Colloid and …, 2022 - Elsevier
Hypothesis: Saponins are a class of plant derived surfactants which are widely used in food
related foams and emulsions, aerated drinks, and in pharmaceuticals and cosmetics. As a …

pH effects on the molecular structure and charging state of β-Escin biosurfactants at the air-water interface

D Glikman, NG Rey, M Richert, K Meister… - Journal of Colloid and …, 2022 - Elsevier
Saponins like β-escin exhibit an unusually high surface activity paired with a remarkable
surface rheology which makes them as biosurfactants highly interesting for applications in …

Amyloid-beta peptide (25–35) triggers a reorganization of lipid membranes driven by temperature changes

O Ivankov, TN Murugova, EV Ermakova, T Kondela… - Scientific Reports, 2021 - nature.com
The amyloid-beta peptide (Aβ) is considered a key factor in Alzheimer's disease (AD) ever
since the discovery of the disease. The understanding of its damaging influence has …

[HTML][HTML] Characterization of size-tuneable aescin-lipid nanoparticles as platform for stabilization of membrane proteins

F Escobedo, M Gospalswamy, P Hägerbäumer… - Colloids and Surfaces B …, 2024 - Elsevier
Disc-like lipid nanoparticles stabilized by saponin biosurfactants display fascinating
properties, including their temperature-driven re-organization. β-Aescin, a saponin from …

Saponins form nonionic lipid nanodiscs for protein structural studies by Nuclear Magnetic Resonance Spectroscopy

SD McCalpin, T Ravula… - The journal of physical …, 2022 - ACS Publications
Structural studies of membrane proteins in native-like environments require the
development of diverse membrane mimetics. Currently there is a need for nanodiscs formed …

Aescin–a natural soap for the formation of lipid nanodiscs with tunable size

R Geisler, MC Pedersen, N Preisig, Y Hannappel… - Soft Matter, 2021 - pubs.rsc.org
The saponin β-aescin from the seed extract of the horse chestnut tree Aesculus
hippocastanum has demonstrated a beneficial role in clinical therapy which is in part related …

Supported lipid bilayer formation from phospholipid-fatty acid bicellar mixtures

TN Sut, S Park, BK Yoon, JA Jackman, NJ Cho - Langmuir, 2020 - ACS Publications
Supported lipid bilayers (SLBs) are versatile cell membrane-mimicking biointerfaces for
various applications such as biosensors and drug delivery systems, and there is broad …

Heating-Induced DMPC/glycyrrhizin bicelle-to-vesicle transition: A X-ray contrast variation study

C Dargel, Y Hannappel, T Hellweg - Biophysical journal, 2020 - cell.com
In this study, we investigated the conversion of lipid bicelles into vesicles in the case of a
system composed of the phospholipid 1, 2-dimyristoyl-sn-glycero-3-phosphocholine …