Accurate proteome-wide missense variant effect prediction with AlphaMissense
The vast majority of missense variants observed in the human genome are of unknown
clinical significance. We present AlphaMissense, an adaptation of AlphaFold fine-tuned on …
clinical significance. We present AlphaMissense, an adaptation of AlphaFold fine-tuned on …
Proteingym: Large-scale benchmarks for protein fitness prediction and design
Predicting the effects of mutations in proteins is critical to many applications, from
understanding genetic disease to designing novel proteins to address our most pressing …
understanding genetic disease to designing novel proteins to address our most pressing …
Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein–Ligand Interactions and High Selectivity
The DNA-encoded library (DEL) discovery platform has emerged as a powerful technology
for hit identification in recent years. It has become one of the major parallel workstreams for …
for hit identification in recent years. It has become one of the major parallel workstreams for …
Maintaining genome integrity: Protein kinases and phosphatases orchestrate the balancing act of DNA double-strand breaks repair in cancer
DNA double-strand breaks (DSBs) are the most lethal DNA damages which lead to severe
genome instability. Phosphorylation is one of the most important protein post-translation …
genome instability. Phosphorylation is one of the most important protein post-translation …
Wip1 inhibits neutrophil extracellular traps to promote abscess formation in mice by directly dephosphorylating Coronin-1a
Y Chen, C Zhao, H Guo, W Zou, Z Zhang… - Cellular & Molecular …, 2023 - nature.com
Neutrophil extracellular traps (NETs) participate in the rapid inhibition and clearance of
pathogens during infection; however, the molecular regulation of NET formation remains …
pathogens during infection; however, the molecular regulation of NET formation remains …
Ppm1d truncating mutations promote the development of genotoxic stress-induced AML
M Burocziova, P Danek, A Oravetzova, Z Chalupova… - Leukemia, 2023 - nature.com
Hematopoietic stem cells (HSCs) ensure blood cell production during the life-time of an
organism, and to do so they need to balance self-renewal, proliferation, differentiation, and …
organism, and to do so they need to balance self-renewal, proliferation, differentiation, and …
[HTML][HTML] Proteingym: Large-scale benchmarks for protein design and fitness prediction
Predicting the effects of mutations in proteins is critical to many applications, from
understanding genetic disease to designing novel proteins that can address our most …
understanding genetic disease to designing novel proteins that can address our most …
Genomics 2 Proteins portal: a resource and discovery tool for linking genetic screening outputs to protein sequences and structures
Recent advances in AI-based methods have revolutionized the field of structural biology.
Concomitantly, high-throughput sequencing and functional genomics have generated …
Concomitantly, high-throughput sequencing and functional genomics have generated …
Discovery of a cryptic pocket in the AI-predicted structure of PPM1D phosphatase explains the binding site and potency of its allosteric inhibitors
Virtual screening is a widely used tool for drug discovery, but its predictive power can vary
dramatically depending on how much structural data is available. In the best case, crystal …
dramatically depending on how much structural data is available. In the best case, crystal …
[PDF][PDF] PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy
PPM1D encodes a phosphatase that is recurrently activated across cancer, most notably in
therapy-related myeloid neoplasms. However, the function of PPM1D in hematopoiesis and …
therapy-related myeloid neoplasms. However, the function of PPM1D in hematopoiesis and …