Artificial intelligence-enabled quantitative phase imaging methods for life sciences

J Park, B Bai, DH Ryu, T Liu, C Lee, Y Luo, MJ Lee… - Nature …, 2023‏ - nature.com
Quantitative phase imaging, integrated with artificial intelligence, allows for the rapid and
label-free investigation of the physiology and pathology of biological systems. This review …

Interferometric scattering microscopy

G Young, P Kukura - Annual review of physical chemistry, 2019‏ - annualreviews.org
Interferometric scattering microscopy (iSCAT) is an extremely sensitive imaging method
based on the efficient detection of light scattered by nanoscopic objects. The ability to, at …

Gradient light interference microscopy for 3D imaging of unlabeled specimens

TH Nguyen, ME Kandel, M Rubessa… - Nature …, 2017‏ - nature.com
Multiple scattering limits the contrast in optical imaging of thick specimens. Here, we present
gradient light interference microscopy (GLIM) to extract three-dimensional information from …

[PDF][PDF] Improved spatiotemporal resolution of anti-scattering super-resolution label-free microscopy via synthetic wave 3D metalens imaging

Y **ao, L Chen, M Pu, M Xu, Q Zhang, Y Guo… - Opto-Electronic …, 2023‏ - researching.cn
Super-resolution (SR) microscopy has dramatically enhanced our understanding of
biological processes. However, scattering media in thick specimens severely limits the …

Epi-illumination gradient light interference microscopy for imaging opaque structures

ME Kandel, C Hu, G Naseri Kouzehgarani… - Nature …, 2019‏ - nature.com
Multiple scattering and absorption limit the depth at which biological tissues can be imaged
with light. In thick unlabeled specimens, multiple scattering randomizes the phase of the field …

Spatial light interference microscopy: principle and applications to biomedicine

X Chen, ME Kandel, G Popescu - Advances in optics and photonics, 2021‏ - opg.optica.org
In this paper, we review spatial light interference microscopy (SLIM), a common-path, phase-
shifting interferometer, built onto a phase-contrast microscope, with white-light illumination …

Quantitative phase imaging (QPI) in neuroscience

C Hu, G Popescu - IEEE Journal of Selected Topics in Quantum …, 2018‏ - ieeexplore.ieee.org
Quantitative phase imaging (QPI) is an emerging label-free modality that attracts significant
interest in biomedicine in general and neuroscience in particular. Based on the principle of …

Label free high speed wide field imaging of single microtubules using interference reflection microscopy

M Mahamdeh, S Simmert, A Łuchniak, E Schäffer… - Biophysical …, 2018‏ - cell.com
504a Tuesday, February 20, 2018 (iSCAT) microscopy, suffer from a number of drawbacks.
For example, contrast dependence on microtubule orientation (DIC), high sensitivity to …

High-speed imaging and tracking of very small single nanoparticles by contrast enhanced microscopy

CY Cheng, YH Liao, CL Hsieh - Nanoscale, 2019‏ - pubs.rsc.org
Nanoparticles have been used extensively in biology-related research and many
applications require direct visualization of individual nanoparticles by optical microscopy …

Quantitative phase imaging reveals matrix stiffness-dependent growth and migration of cancer cells

Y Li, MJ Fanous, KA Kilian, G Popescu - Scientific reports, 2019‏ - nature.com
Cancer progression involves complex signals within the tumor microenvironment that
orchestrate proliferation and invasive processes. The mechanical properties of the …