Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of
proteins have a major impact on the pharmacological behavior of most of the drugs in use …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

▪ Abstract The ATP-binding cassette (ABC) transporters are a family of large proteins in
membranes and are able to transport a variety of compounds through membranes against …

Molecular medicine has led to rapid advances in the characterization of hepatobiliary
transport systems that determine the uptake and excretion of bile salts and other biliary …

Despite many scientific advances, human exposure to, and intoxication by, toxic metal
species continues to occur. Surprisingly, little is understood about the mechanisms by which …

Mercury is unique among the heavy metals in that it can exist in several physical and
chemical forms, including elemental mercury, which is a liquid at room temperature. All …

Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins
named ATP-binding cassette (ABC) transporters. These ABC transporters together form the …

Cadmium (Cd) is an industrial and environmental pollutant that affects adversely a number
of organs in humans and other mammals, including the kidneys, liver, lungs, pancreas …

Many orally administered drugs must overcome several barriers before reaching their target
site. The first major obstacle to cross is the intestinal epithelium. Although lipophilic …

The MRP family is comprised of nine related ABC transporters that are able to transport
structurally diverse lipophilic anions and function as drug efflux pumps. Investigations of this …