This study presents a comprehensive analysis of purine analogues, focusing on their
biological evaluations, including antioxidant, cytotoxic activity, and enzyme inhibition …

In terms of fused heterocyclic compounds, pyrrolopyrimidines, and their substituted analogs
are among the most extensively explored scaffolds. Based on the location of the nitrogen …

To date, viruses are known to cause chronic to acute pathogenesis. Nevertheless, antiviral
drugs have been known for their medicinal applications for the last few decades to treat …

A series of novel naphthopyrano [2, 3-d] pyrimidin-11 (12 H)-one containing isoxazole
nucleus 4 was synthesized under microwave irradiation and classical conditions in …

Zika virus (ZIKV) is a mosquito-borne virus belonging to the Flaviviridae family and is
responsible for an exanthematous disease and severe neurological manifestations, such as …

To search for Zika virus (ZIKV) antivirals, we have further explored previously reported 7 H-
pyrrolo [2, 3-d] pyrimidines by examining an alternative substitution pattern of their central …

Every year, dengue virus affects hundreds of millions of individuals worldwide. To date,
there is no specific medication to treat dengue virus infections. Nucleobases, the base of a …

Pyrimidine-fused heterocyclic compounds exhibit pharmacological activity, including anti-
diabetic and antibacterial, antifungal properties. This study involves the design and …

A series of six bis-furyl-pyrrolo [3, 4-b] pyridin-5-ones synthesized via an Ugi-Zhu reaction
coupled to a cascade process [aza Diels-Alder cycloaddition/N-acylation/aromatization] …

The importance of R&D of new antivirals has been highly evident with the emergence of the
pandemic caused by SARS‐CoV‐2. Pyrimidines are heterocyclic compounds with a broad …