The combination of spatial transcriptomics (ST) and single cell RNA sequencing (scRNA-
seq) acts as a pivotal component to bridge the pathological phenomes of human tissues with …

The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …

The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) are
poorly understood, hindering patient treatment. In the current study, we investigate whether …

Blood production depends on rare haematopoietic stem cells (HSCs) and haematopoietic
stem and progenitor cells (HSPCs) that ultimately take up residence in the bone marrow …

Macrophages are vital tissue components involved in organogenesis, maintaining
homeostasis, and responses to disease. Mouse models have significantly improved our …

Recent advancements in modern science have provided robust tools for drug discovery. The
rapid development of transcriptome sequencing technologies has given rise to single-cell …

Hematopoiesis is regulated by the bone marrow (BM) stroma. However, cellular identities
and functions of the different BM stromal elements in humans remain poorly defined. Based …

The proper functioning of diverse biological systems depends on the spatial organization of
their cells, a critical factor for biological processes like sha** intricate tissue functions and …

Demand-adjusted and cell type specific rates of protein synthesis represent an important
safeguard for fate and function of long-term hematopoietic stem cells. Here, we identify …

Liver disease is prevalent worldwide. When it reaches the end stage, mortality rises to 50%
or more. Although liver transplantation has emerged as the most efficient treatment for end …