Protein analysis by shotgun/bottom-up proteomics
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways
There have been numerous attempts to develop non-opioid drugs for severe pain, but the
vast majority of these efforts have failed. A notable exception is Ziconotide (Prialt®) …
vast majority of these efforts have failed. A notable exception is Ziconotide (Prialt®) …
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins
Y Chen, R Wan, Z Zou, L Lao, G Shao, Y Zheng… - Nature Cell …, 2023 - nature.com
Abstract N 6-methyladenosine (m6A) is the most abundant internal mRNA nucleotide
modification in mammals, regulating critical aspects of cell physiology and differentiation …
modification in mammals, regulating critical aspects of cell physiology and differentiation …
A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides
We describe pLink 2, a search engine with higher speed and reliability for proteome-scale
identification of cross-linked peptides. With a two-stage open search strategy facilitated by …
identification of cross-linked peptides. With a two-stage open search strategy facilitated by …
pGlyco 2.0 enables precision N-glycoproteomics with comprehensive quality control and one-step mass spectrometry for intact glycopeptide identification
The precise and large-scale identification of intact glycopeptides is a critical step in
glycoproteomics. Owing to the complexity of glycosylation, the current overall throughput …
glycoproteomics. Owing to the complexity of glycosylation, the current overall throughput …
Chemical proteomics reveals new targets of cysteine sulfinic acid reductase
Cysteine sulfinic acid or S-sulfinylation is an oxidative post-translational modification
(OxiPTM) that is known to be involved in redox-dependent regulation of protein function but …
(OxiPTM) that is known to be involved in redox-dependent regulation of protein function but …
quantms: a cloud-based pipeline for quantitative proteomics enables the reanalysis of public proteomics data
C Dai, J Pfeuffer, H Wang, P Zheng, L Käll… - Nature …, 2024 - nature.com
The volume of public proteomics data is rapidly increasing, causing a computational
challenge for large-scale reanalysis. Here, we introduce quantms (https://quant, ms. org/), an …
challenge for large-scale reanalysis. Here, we introduce quantms (https://quant, ms. org/), an …
Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans
Abstract Insulin/IGF-1 Signaling (IIS) is known to constrain longevity by inhibiting the
transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan …
transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan …
A mechanism for oxidative damage repair at gene regulatory elements
Oxidative genome damage is an unavoidable consequence of cellular metabolism. It arises
at gene regulatory elements by epigenetic demethylation during transcriptional activation …
at gene regulatory elements by epigenetic demethylation during transcriptional activation …
Structure of the activated human minor spliceosome
INTRODUCTION Precursor messenger RNA (pre-mRNA) splicing, which involves the
removal of noncoding introns and the ligation of the coding exons, is achieved by the …
removal of noncoding introns and the ligation of the coding exons, is achieved by the …