The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to
respiratory illness and multi-organ failure in critically ill patients. Although the virus-induced …

Caspases are an evolutionary conserved family of cysteine proteases that are centrally
involved in cell death and inflammation responses. A wealth of foundational insight into the …

Invasive candidiasis is an important health-care-associated fungal infection that can be
caused by several Candida spp.; the most common species is Candida albicans, but the …

The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require
cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and …

Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-
forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1-and …

Cell death is central to development, organismal homeostasis, and immune responses. The
cell death field has experienced tremendous progress by delineating the molecular …