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Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis
Metabolism was once relegated to the supply of energy and biosynthetic precursors, but it
has now become clear that it is a specific mediator of nearly all physiological processes. In …
has now become clear that it is a specific mediator of nearly all physiological processes. In …
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
Immunological tests provide evidence of latent tuberculosis in one third of the global
population, which corresponds to more than two billion individuals. Latent tuberculosis is …
population, which corresponds to more than two billion individuals. Latent tuberculosis is …
Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis
Antibacterial agents target the products of essential genes but rarely achieve complete
target inhibition. Thus, the all-or-none definition of essentiality afforded by traditional genetic …
target inhibition. Thus, the all-or-none definition of essentiality afforded by traditional genetic …
Neutrophils are the predominant infected phagocytic cells in the airways of patients with active pulmonary TB
SY Eum, JH Kong, MS Hong, YJ Lee, JH Kim… - Chest, 2010 - Elsevier
Background The exact role of neutrophils in the pathogenesis of TB is poorly understood.
Recent evidence suggests that neutrophils are not simply scavenging phagocytes in …
Recent evidence suggests that neutrophils are not simply scavenging phagocytes in …
The Mycobacterium tuberculosis DosR Regulon Assists in Metabolic Homeostasis and Enables Rapid Recovery from Nonrespiring Dormancy
RL Leistikow, RA Morton, IL Bartek… - Journal of …, 2010 - journals.asm.org
Mycobacterium tuberculosis survives in latently infected individuals, likely in a
nonreplicating or dormancy-like state. The M. tuberculosis DosR regulon is a genetic …
nonreplicating or dormancy-like state. The M. tuberculosis DosR regulon is a genetic …
Mycobacterium tuberculosis WhiB3 Maintains Redox Homeostasis by Regulating Virulence Lipid Anabolism to Modulate Macrophage Response
The metabolic events associated with maintaining redox homeostasis in Mycobacterium
tuberculosis (Mtb) during infection are poorly understood. Here, we discovered a novel …
tuberculosis (Mtb) during infection are poorly understood. Here, we discovered a novel …
Reengineering Redox Sensitive GFP to Measure Mycothiol Redox Potential of Mycobacterium tuberculosis during Infection
A Bhaskar, M Chawla, M Mehta, P Parikh… - PLoS …, 2014 - journals.plos.org
Mycobacterium tuberculosis (Mtb) survives under oxidatively hostile environments
encountered inside host phagocytes. To protect itself from oxidative stress, Mtb produces …
encountered inside host phagocytes. To protect itself from oxidative stress, Mtb produces …
Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions
Metabolic coupling of Mycobacterium tuberculosis to its host is foundational to its
pathogenesis. Computational genome‐scale metabolic models have shown utility in …
pathogenesis. Computational genome‐scale metabolic models have shown utility in …
Niacinamide-mechanisms of action and its topical use in dermatology
J Wohlrab, D Kreft - Skin pharmacology and physiology, 2014 - karger.com
Niacinamide, an amide of vitamin B 3 (niacin), is a hydrophilic endogenous substance. Its
effects after epicutaneous application have long been described in the literature. Given a …
effects after epicutaneous application have long been described in the literature. Given a …
Redox homeostasis in mycobacteria: the key to tuberculosis control?
Mycobacterium tuberculosis (Mtb) is a metabolically flexible pathogen that has the
extraordinary ability to sense and adapt to the continuously changing host environment …
extraordinary ability to sense and adapt to the continuously changing host environment …