Despite an improved understanding of cancer molecular biology, immune landscapes, and
advancements in cytotoxic, biologic, and immunologic anti-cancer therapeutics, cancer …

Despite the exciting properties and wide-reaching applications of nanobiomaterials (NBMs)
in human health and medicine, their translation from bench to bedside is slow, with a …

Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors,
and many patients are diagnosed with advanced disease. The treatment of advanced liver …

Porcine cancer models offer a valuable platform for evaluating interventions such as
devices, surgeries, and locoregional therapies, which are often challenging to test in mouse …

DNA-methylation profiles have been used successfully to develop highly accurate
biomarkers of age, epigenetic clocks, for many species. Using a custom methylation array …

Enhanced understanding of the molecular features of glioma has led to an expansion of
murine glioma models and successful preclinical studies. However, clinical trials continue to …

The immune system plays dual roles in response to cancer. The host immune system
protects against tumor formation via immunosurveillance; however, recognition of the tumor …

For patients diagnosed with advanced and unresectable hepatocellular carcinoma (HCC),
liver transplantation remains the best option to extend life. Challenges with organ supply …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death
worldwide. New animal models that faithfully recapitulate human HCC phenotypes are …

Although survival has improved in recent years, the prognosis of patients with advanced
pancreatic ductal adenocarcinoma (PDAC) remains poor. Despite substantial differences in …