Stress and cancer: mechanisms, significance and future directions

A Eckerling, I Ricon-Becker, L Sorski… - Nature Reviews …, 2021 - nature.com
The notion that stress and cancer are interlinked has dominated lay discourse for decades.
More recent animal studies indicate that stress can substantially facilitate cancer …

The cancer-immune dialogue in the context of stress

Y Ma, G Kroemer - Nature Reviews Immunology, 2024 - nature.com
Although there is little direct evidence supporting that stress affects cancer incidence, it does
influence the evolution, dissemination and therapeutic outcomes of neoplasia, as shown in …

Anoikis resistance––protagonists of breast cancer cells survive and metastasize after ECM detachment

Y Dai, X Zhang, Y Ou, L Zou, D Zhang, Q Yang… - Cell Communication and …, 2023 - Springer
Breast cancer exhibits the highest global incidence among all tumor types. Regardless of
the type of breast cancer, metastasis is a crucial cause of poor prognosis. Anoikis, a form of …

FAK in cancer: mechanistic findings and clinical applications

FJ Sulzmaier, C Jean, DD Schlaepfer - Nature reviews cancer, 2014 - nature.com
Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

Sympathetic nervous system regulation of the tumour microenvironment

SW Cole, AS Nagaraja, SK Lutgendorf… - Nature Reviews …, 2015 - nature.com
The peripheral autonomic nervous system (ANS) is known to regulate gene expression in
primary tumours and their surrounding microenvironment. Activation of the sympathetic …

Exploiting the critical perioperative period to improve long-term cancer outcomes

M Horowitz, E Neeman, E Sharon… - Nature reviews Clinical …, 2015 - nature.com
Evidence suggests that the perioperative period and the excision of the primary tumour can
promote the development of metastases—the main cause of cancer-related mortality. This …

Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells

B Cui, Y Luo, P Tian, F Peng, J Lu, Y Yang, Q Su… - The Journal of clinical …, 2019 - jci.org
Chronic stress triggers activation of the sympathetic nervous system and drives malignancy.
Using an immunodeficient murine system, we showed that chronic stress–induced …

Neurotransmitters: emerging targets in cancer

SH Jiang, LP Hu, X Wang, J Li, ZG Zhang - Oncogene, 2020 - nature.com
Neurotransmitters are conventionally viewed as nerve-secreted substances that mediate the
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …

FAK signaling in human cancer as a target for therapeutics

BY Lee, P Timpson, LG Horvath, RJ Daly - Pharmacology & therapeutics, 2015 - Elsevier
Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …

Molecular pathways: beta-adrenergic signaling in cancer

SW Cole, AK Sood - Clinical cancer research, 2012 - aacrjournals.org
Beta-adrenergic signaling has been found to regulate multiple cellular processes that
contribute to the initiation and progression of cancer, including inflammation, angiogenesis …