Stress and cancer: mechanisms, significance and future directions
A Eckerling, I Ricon-Becker, L Sorski… - Nature Reviews …, 2021 - nature.com
The notion that stress and cancer are interlinked has dominated lay discourse for decades.
More recent animal studies indicate that stress can substantially facilitate cancer …
More recent animal studies indicate that stress can substantially facilitate cancer …
The cancer-immune dialogue in the context of stress
Y Ma, G Kroemer - Nature Reviews Immunology, 2024 - nature.com
Although there is little direct evidence supporting that stress affects cancer incidence, it does
influence the evolution, dissemination and therapeutic outcomes of neoplasia, as shown in …
influence the evolution, dissemination and therapeutic outcomes of neoplasia, as shown in …
Anoikis resistance––protagonists of breast cancer cells survive and metastasize after ECM detachment
Y Dai, X Zhang, Y Ou, L Zou, D Zhang, Q Yang… - Cell Communication and …, 2023 - Springer
Breast cancer exhibits the highest global incidence among all tumor types. Regardless of
the type of breast cancer, metastasis is a crucial cause of poor prognosis. Anoikis, a form of …
the type of breast cancer, metastasis is a crucial cause of poor prognosis. Anoikis, a form of …
FAK in cancer: mechanistic findings and clinical applications
FJ Sulzmaier, C Jean, DD Schlaepfer - Nature reviews cancer, 2014 - nature.com
Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …
Sympathetic nervous system regulation of the tumour microenvironment
The peripheral autonomic nervous system (ANS) is known to regulate gene expression in
primary tumours and their surrounding microenvironment. Activation of the sympathetic …
primary tumours and their surrounding microenvironment. Activation of the sympathetic …
Exploiting the critical perioperative period to improve long-term cancer outcomes
M Horowitz, E Neeman, E Sharon… - Nature reviews Clinical …, 2015 - nature.com
Evidence suggests that the perioperative period and the excision of the primary tumour can
promote the development of metastases—the main cause of cancer-related mortality. This …
promote the development of metastases—the main cause of cancer-related mortality. This …
Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells
B Cui, Y Luo, P Tian, F Peng, J Lu, Y Yang, Q Su… - The Journal of clinical …, 2019 - jci.org
Chronic stress triggers activation of the sympathetic nervous system and drives malignancy.
Using an immunodeficient murine system, we showed that chronic stress–induced …
Using an immunodeficient murine system, we showed that chronic stress–induced …
Neurotransmitters: emerging targets in cancer
Neurotransmitters are conventionally viewed as nerve-secreted substances that mediate the
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …
FAK signaling in human cancer as a target for therapeutics
Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …
mediated signals, governing fundamental processes in normal and cancer cells through its …
Molecular pathways: beta-adrenergic signaling in cancer
SW Cole, AK Sood - Clinical cancer research, 2012 - aacrjournals.org
Beta-adrenergic signaling has been found to regulate multiple cellular processes that
contribute to the initiation and progression of cancer, including inflammation, angiogenesis …
contribute to the initiation and progression of cancer, including inflammation, angiogenesis …