Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …

Remyelination involves reinvesting demyelinated axons with new myelin sheaths. In stark
contrast to the situation that follows loss of neurons or axonal damage, remyelination in the …

Intravenous immune globulin has been used in the treatment of primary and secondary
antibody deficiencies for more than 25 years. It is a safe preparation with no long-term side …

Multiple sclerosis is a common cause of neurological disability in young adults. The disease
is complex—its aetiology is multifactorial and largely unknown; its pathology is …

Interleukin-1β (IL-1β) is a proinflammatory cytokine associated with the pathophysiology of
demyelinating disorders such as multiple sclerosis and viral infections of the CNS. However …

The inability of the mammalian central nervous system (CNS) to undergo spontaneous
regeneration has long been regarded as a central tenet of neurobiology. However, although …

Multiple sclerosis is (MS) a T‐cell autoimmune disease characterized by a relapsing‐
remitting followed by a progressive phase. Relapses are driven by the adaptive immune …

Mesenchymal stem cell-derived exosome is a safe and effective delivery platform with a
potential capacity to exert immunomodulation effect and peripheral tolerance toward auto …

Theiler's virus infection of the CNS induces an immune-mediated demyelinating disease in
susceptible mouse strains and serves as a relevant infection model for human multiple …

Both genetic background and environmental factors, very probably viruses, appear to play a
role in the etiology of multiple sclerosis (MS). Lessons from viral experimental models …