Biochemical and mechanical regulation of actin dynamics

P Lappalainen, T Kotila, A Jégou… - … Reviews Molecular Cell …, 2022 - nature.com
Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

Effects of extracellular matrix viscoelasticity on cellular behaviour

O Chaudhuri, J Cooper-White, PA Janmey, DJ Mooney… - Nature, 2020 - nature.com
Substantial research over the past two decades has established that extracellular matrix
(ECM) elasticity, or stiffness, affects fundamental cellular processes, including spreading …

Viscoelastic cell microenvironment: hydrogel‐based strategy for recapitulating dynamic ECM mechanics

Y Ma, T Han, Q Yang, J Wang, B Feng… - Advanced Functional …, 2021 - Wiley Online Library
The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and
displays time‐dependent responses to deformation or mechanical loading, in terms of …

Actin dynamics, architecture, and mechanics in cell motility

L Blanchoin, R Boujemaa-Paterski… - Physiological …, 2014 - journals.physiology.org
Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

Viscoelastic hydrogels for 3D cell culture

O Chaudhuri - Biomaterials science, 2017 - pubs.rsc.org
In tissues, many cells are surrounded by and interact with a three-dimensional soft
extracellular matrix (ECM). Both the physical and biochemical properties of the ECM play a …

Modeling semiflexible polymer networks

CP Broedersz, FC MacKintosh - Reviews of Modern Physics, 2014 - APS
This is an overview of theoretical approaches to semiflexible polymers and their networks.
Such semiflexible polymers have large bending rigidities that can compete with the entropic …

Strain-enhanced stress relaxation impacts nonlinear elasticity in collagen gels

S Nam, KH Hu, MJ Butte, O Chaudhuri - Proceedings of the National …, 2016 - pnas.org
The extracellular matrix (ECM) is a complex assembly of structural proteins that provides
physical support and biochemical signaling to cells in tissues. The mechanical properties of …

Cell mechanics and the cytoskeleton

DA Fletcher, RD Mullins - Nature, 2010 - nature.com
The ability of a eukaryotic cell to resist deformation, to transport intracellular cargo and to
change shape during movement depends on the cytoskeleton, an interconnected network of …

Investigating cell mechanics with atomic force microscopy

K Haase, AE Pelling - Journal of The Royal Society …, 2015 - royalsocietypublishing.org
Transmission of mechanical force is crucial for normal cell development and functioning.
However, the process of mechanotransduction cannot be studied in isolation from cell …

Dynamic molecular processes mediate cellular mechanotransduction

BD Hoffman, C Grashoff, MA Schwartz - Nature, 2011 - nature.com
Cellular responses to mechanical forces are crucial in embryonic development and adult
physiology, and are involved in numerous diseases, including atherosclerosis …