Strong evidence suggests that early-life exposures to suboptimal environmental factors,
including those in utero, influence our long-term metabolic health. This has been termed …

The use of in vitro tools to study trophoblast differentiation and function is essential to
improve understanding of normal and abnormal placental development. The relative …

The placenta is vital for mammalian development and a key determinant of life‐long health.
It is the interface between the mother and fetus and is responsible for transporting the …

In vivo and in vitro studies demonstrate that mitochondria in the oocyte, are susceptible to
damage by suboptimal pre/pregnancy conditions, such as obesity. These suboptimal …

Decidualisation of the endometrium is a key event in early pregnancy, which enables
embryo implantation. Importantly, the molecular processes impairing decidualisation in …

The placenta is particularly susceptible to inflammation and oxidative stress, leading to
placental vascular dysfunction and placental insufficiency, which is associated with fetal …

Maternal obesity increases the risk of childhood obesity and programs the offspring to
develop metabolic syndrome later in their life. Palmitate is the predominant saturated free …

Aims Diets containing high‐fat and high sugar (HFHS) lead to overweight/obesity.
Overweight/obesity increases the risk of infertility, and of the pregnant mother and her child …

Obesity is rising globally and is associated with neurodevelopmental and psychiatric
disorders among children, adolescents and young adults. Whether obesity is the cause or …

Melatonin supplementation to obese mothers during gestation and lactation might benefit
the pancreatic islet cellular composition and beta-cell function in male offspring adulthood …