Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Among all cells, fibroblasts could be considered the cockroaches of the human body. They
survive severe stress that is usually lethal to all other cells, and they are the only normal cell …

Tumorigenesis is a complex and dynamic process involving different cellular and non-
cellular elements composed of tumor microenvironment (TME). The interaction of TME with …

The epithelial‐mesenchymal transition (EMT) is a transformation process mandatory for the
local and distant progression of many malignant tumors, including hepatocellular carcinoma …

The tumor microenvironment comprises a mass of heterogeneous cell types, including
immune cells, endothelial cells, and fibroblasts, alongside cancer cells. It is increasingly …

The development of the mammary gland is unique: the final stages of development occur
postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of …

Extracellular proteolysis mediates tissue homeostasis. In cancer, altered proteolysis leads to
unregulated tumor growth, tissue remodeling, inflammation, tissue invasion, and metastasis …

A vast ensemble of extracellular proteins influences the development and progression of
cancer, shaped and reshaped by a complex network of extracellular proteases. These …

Tumor cells exist in close proximity with non-malignant cells. Extensive and multilayered
crosstalk between tumor cells and stromal cells tailors the tumor microenvironment (TME) to …

Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the
extracellular matrix. These proteinases play a central role in many biological processes …