Aims The inflammation modulation effects of mesenchymal stromal cell-derived exosomes
(MSC-EXO) are well established. We aimed to explore the mechanism behind the …

Ubiquitin-conjugating enzymes (E2s) are one of the three enzymes required by the ubiquitin-
proteasome pathway to connect activated ubiquitin to target proteins via ubiquitin ligases …

Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal
prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis …

Digestive system cancers are the leading cause of cancer-related death worldwide due to
their high morbidity and mortality rates. The current treatment methods include surgical …

Most hepatocellular carcinoma (HCC) patients are diagnosed at an advanced stage;
however, the effect of systemic therapy on advanced HCC remains undetermined …

Despite liver cancer being the second-leading cause of cancer-related death worldwide, few
systemic drugs have been approved. Sorafenib, the first FDA-approved systemic drug for …

Background: GDP Dissociation inhibitor 2 (GDI2) gene has been correlated with some
important biological processes in a variety of cancers, whereas the role of GDI2 in …

Objective: This study intends to identify potential prognostic marker genes associated with
the prognosis of patients suffering from hepatocellular carcinoma (HCC) based on TCGA …

Hepatocellular carcinoma (HCC) ranks one of the most common and lethal cancers all over
the world. Previous studies suggest that ubiquitin-conjugating enzyme E2C (UBE2C) serves …

Background Treatment options for hepatocellular carcinoma (HCC) are limited, and overall
survival is poor. Despite the high frequency of this malignoma, its basic disease …