Tuberculosis, a disease of poverty is a communicable infection with a reasonably high
mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million …

Molecular hybridization is one of the recent stratagems in medicinal chemistry to synthesize
a novel hybrid molecule having better affinity and efficacy by combining two or more …

The current study investigated the cytotoxic effect of ten sulfonamide-derived isatins,
following molecular hybridization, based on the association principles, on hepatocellular …

4-Phenyl-3-[2-(phenylamino) ethyl]-1 H-1, 2, 4-triazole-5 (4 H)-thione was used as a starting
compound for the synthesis of the corresponding 1, 2, 4-triazol-3-ylthioacetohydrazide …

Carbonyl–carbonyl (CO⋯ CO) interactions are recently explored noncovalent interactions of
significant interest owing to their role in the stability of biomacromolecules. Currently …

The current work comprises theoretical studies on spiro [1H-indole-3, 2′-3H-1, 3-
benzothiazole]-2-one employing density functional theory (DFT). The optimized structure …

Antibiotic resistance is rapidly evolving at an alarming rate, posing a severe threat to
humanity. In an effort to develop compounds with antimicrobial activity, we synthesized a …

A series of new fluorinated 1-benzylisatins was synthesized in high yields via a simple one-
pot procedure in order to explore the possible effect of ortho-fluoro (3a), chloro (3b), or bis …

Monoamine oxidase (MAO, EC 1.4. 3.4) is responsible for the oxidative breakdown of both
endogenous and exogenous amines and exists in MAO-A and MAO-B isomers. Eighteen …

Abstract α-Glucosidase and urease inhibitors have emerged as crucial for develo**
therapeutic drugs targeting diabetes and gastrointestinal disorders. This study reports on …