Mitochondrial impairment is a well-established pathological pathway implicated in
Parkinson's disease (PD). Defects of the complex I of the mitochondrial respiratory chain …

Aging is the time-dependent functional decline that increases the vulnerability to different
forms of stress, constituting the major risk factor for the development of neurodegenerative …

Presynaptic terminals are metabolically active and accrue damage through continuous
vesicle cycling. How synapses locally regulate protein homeostasis is poorly understood …

Molecular chaperones are a family of proteins that maintain cellular protein homeostasis
through non-covalent peptide folding and quality control mechanisms. The chaperone …

Parkinson's disease (PD) is characterised by the loss of dopaminergic neurons in the
midbrain. Autosomal recessive, early‐onset cases of PD are predominantly caused by …

The mitochondrial chaperone mortalin was implicated in Parkinson's disease (PD) because
of its reduced levels in the brains of PD patients and disease-associated rare genetic …

Quality control of peroxisomes is essential for cellular homeostasis. However, the
mechanism underlying pexophagy is largely unknown. In this study, we identified HSPA9 as …

Mortalin/mtHsp70 is a member of Hsp70 family of proteins. Enriched in a large variety of
cancers, it has been shown to contribute to the process of carcinogenesis by multiple ways …

Mortalin is a chaperone protein that regulates physiological functions of cells. Its
multifactorial role allows cells to survive pathological conditions. Pharmacological, chemical …

Sarcopenia is a systemic skeletal muscle disease characterized by a decline in skeletal
muscle mass and function. Originally defined as an age‐associated condition, sarcopenia …