The mechanisms of Hedgehog signalling and its roles in development and disease
The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …
decades ago inaugurated a field that has diversified to encompass embryonic development …
Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches
Skin cancer is a global threat to the healthcare system and is estimated to incline
tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is …
tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is …
G protein-coupled receptors: novel targets for drug discovery in cancer
G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …
proteins that have a pivotal role in many physiological functions and in multiple diseases …
Mechanisms and functions of Hedgehog signalling across the metazoa
PW Ingham, Y Nakano, C Seger - Nature reviews genetics, 2011 - nature.com
Hedgehog proteins constitute one of a small number of families of secreted signals that have
a central role in the development of metazoans. Genetic analyses in flies, fish and mice have …
a central role in the development of metazoans. Genetic analyses in flies, fish and mice have …
Smoothened variants explain the majority of drug resistance in basal cell carcinoma
Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened
(SMO) inhibitors through unknown mechanisms. Here we identify SMO mutations in 50%(22 …
(SMO) inhibitors through unknown mechanisms. Here we identify SMO mutations in 50%(22 …
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
Hedgehog signalling is fundamental to embryonic development and postnatal tissue
regeneration. Aberrant postnatal Hedgehog signalling leads to several malignancies …
regeneration. Aberrant postnatal Hedgehog signalling leads to several malignancies …
Structure of the human smoothened receptor bound to an antitumour agent
The smoothened (SMO) receptor, a key signal transducer in the hedgehog signalling
pathway, is responsible for the maintenance of normal embryonic development and is …
pathway, is responsible for the maintenance of normal embryonic development and is …
Biochemical mechanisms of vertebrate hedgehog signaling
Signaling pathways that mediate cell-cell communication are essential for collective cell
behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and …
behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and …
G protein-coupled receptor kinases: more than just kinases and not only for GPCRs
G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …
WNT/F rizzled signalling: receptor–ligand selectivity with focus on FZD‐G protein signalling and its physiological relevance: IUPHAR Review 3
The wingless/int1 (WNT)/F rizzled (FZD) signalling pathway controls numerous cellular
processes such as proliferation, differentiation, cell‐fate decisions, migration and plays a …
processes such as proliferation, differentiation, cell‐fate decisions, migration and plays a …