CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly
validated signal for promoting a variety of common diseases, particularly in the …

Atrial fibrillation (AF), the most common cardiac arrhythmia worldwide, is driven by complex
mechanisms that differ between subgroups of patients. This complexity is apparent from the …

Background: Cardiac ischemia/reperfusion (I/R) injury has emerged as an important
therapeutic target for ischemic heart disease, the leading cause of morbidity and mortality …

Atrial fibrillation (AF) is the most frequent arrhythmia and is associated with substantial
morbidity and mortality. Pathophysiological aspects consist in the activation of pro-fibrotic …

Cardiovascular diseases are the leading cause of morbidity and mortality worldwide,
highlighting the high socioeconomic impact. Current treatment strategies like compound …

Introduction Supraventricular tachycardias (SVT) are a diverse group of commonly
encountered arrhythmias arising at or above the atrioventricular (AV) node. Conventional …

BACKGROUND: Cardiovascular diseases are the main cause of worldwide morbidity and
mortality, highlighting the need for new therapeutic strategies. Autophosphorylation and …

Rationale: Increased myocardial activity of CaMKII (Ca/calmodulin-dependent kinase II)
leads to heart failure and arrhythmias. In Drosophila neurons, interaction of CaMKII with …

Cardiovascular disease is the leading cause of death worldwide. In spite of the mature
managements of myocardial infarction (MI), post-MI reperfusion (I/R) injury results in high …

Myocardial infarction and revascularization cause cardiac ischemia/reperfusion (I/R) injury
featuring cardiomyocyte death and inflammation. The Ca 2+/calmodulin dependent protein …