miRNAs role in bladder cancer pathogenesis and targeted therapy: signaling pathways interplay–a review

HA El-Mahdy, EGE Elsakka, AA El-Husseiny… - … -Research and Practice, 2023 - Elsevier
Bladder cancer (BC) is the 11th most popular cancer in females and 4th in males. A lot of
efforts have been exerted to improve BC patients' care. Besides, new approaches have …

Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity

MA Knowles, CD Hurst - Nature reviews cancer, 2015 - nature.com
Urothelial carcinoma of the bladder comprises two long-recognized disease entities with
distinct molecular features and clinical outcome. Low-grade non-muscle-invasive tumours …

The miR-200 family of microRNAs: fine tuners of epithelial-mesenchymal transition and circulating cancer biomarkers

I Cavallari, F Ciccarese, E Sharova, L Urso… - Cancers, 2021 - mdpi.com
Simple Summary MicroRNAs (miRNAs) are small RNA molecules that regulate gene
expression by blocking translation or inducing degradation of specific gene transcripts. The …

PRMT5 circular RNA promotes metastasis of urothelial carcinoma of the bladder through sponging miR-30c to induce epithelial–mesenchymal transition

X Chen, RX Chen, WS Wei, YH Li, ZH Feng, L Tan… - Clinical Cancer …, 2018 - AACR
Abstract Purpose: Circular RNAs (circRNAs), a novel class of noncoding RNAs, have
recently drawn lots of attention in the pathogenesis of human cancers. However, the role of …

MicroRNA and cancer–a brief overview

M Acunzo, G Romano, D Wernicke… - Advances in biological …, 2015 - Elsevier
MicroRNAs (miRNAs) are short non-coding RNAs with a length of∼ 22 nucleotides,
involved in posttranscriptional regulation of gene expression. Until now, over 2588 miRNAs …

ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

P Zhang, Y Sun, L Ma - Cell cycle, 2015 - Taylor & Francis
Zinc finger E-box binding homeobox 1 (ZEB1) is a transcription factor that promotes tumor
invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) in carcinoma …

Understanding the effectiveness of natural compound mixtures in cancer through their molecular mode of action

TN Aung, Z Qu, RD Kortschak, DL Adelson - International journal of …, 2017 - mdpi.com
Many approaches to cancer management are often ineffective due to adverse reactions,
drug resistance, or inadequate target specificity of single anti-cancer agents. In contrast, a …

The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective

V Das, S Bhattacharya… - Journal of cellular …, 2019 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) is a key step in transdifferentiation process in solid
cancer development. Forthcoming evidence suggest that the stratified program transforms …

MicroRNAs in human cancer

TA Farazi, JI Hoell, P Morozov, T Tuschl - MicroRNA cancer regulation …, 2013 - Springer
Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20–23-nucleotide (nt)
length that control gene expression in many cellular processes. These molecules typically …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …