Metals to combat antimicrobial resistance

A Frei, AD Verderosa, AG Elliott, J Zuegg… - Nature Reviews …, 2023 - nature.com
Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …

New antimicrobial strategies based on metal complexes

M Claudel, JV Schwarte, KM Fromm - Chemistry, 2020 - mdpi.com
Traditional organic antimicrobials mainly act on specific biochemical processes such as
replication, transcription and translation. However, the emergence and wide spread of …

Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains

A Müller, M Wenzel, H Strahl, F Grein… - Proceedings of the …, 2016 - National Acad Sciences
Daptomycin is a highly efficient last-resort antibiotic that targets the bacterial cell membrane.
Despite its clinical importance, the exact mechanism by which daptomycin kills bacteria is …

N, S, and P-co-doped carbon quantum dots: intrinsic peroxidase activity in a wide pH range and its antibacterial applications

KM Tripathi, HT Ahn, M Chung, XA Le… - ACS Biomaterials …, 2020 - ACS Publications
Nanozymes have drawn significant scientific interest due to their high practical importance in
terms of overcoming the instability, complicated synthesis, and high cost of protein enzymes …

Metal complexes, an untapped source of antibiotic potential?

A Frei - Antibiotics, 2020 - mdpi.com
With the widespread rise of antimicrobial resistance, most traditional sources for new drug
compounds have been explored intensively for new classes of antibiotics. Meanwhile, metal …

Multitarget approaches against multiresistant superbugs

DA Gray, M Wenzel - ACS Infectious Diseases, 2020 - ACS Publications
Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for
drug discovery to keep pace. Often, resistance against a new drug develops even before it …

Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First In Vivo Experiments

A Frei, AG Elliott, A Kan, H Dinh, S Bräse, AE Bruce… - JACS au, 2022 - ACS Publications
There are currently fewer than 10 antifungal drugs in clinical development, but new fungal
strains that are resistant to most current antifungals are spreading rapidly across the world …

Analysis of antimicrobial-triggered membrane depolarization using voltage sensitive dyes

JD Te Winkel, DA Gray, KH Seistrup… - Frontiers in cell and …, 2016 - frontiersin.org
The bacterial cytoplasmic membrane is a major inhibitory target for antimicrobial
compounds. Commonly, although not exclusively, these compounds unfold their …

Multi-functional fluorescent carbon dots with antibacterial and gene delivery properties

Q Dou, X Fang, S Jiang, PL Chee, TC Lee, XJ Loh - Rsc Advances, 2015 - pubs.rsc.org
Glucose is abundant in nature and can be found in various sources. In this study, we
developed multifunctional carbon dots (CDs) with glucose and poly (ethyleneimine)(PEI) …

Recent development of luminescent rhenium (I) tricarbonyl polypyridine complexes as cellular imaging reagents, anticancer drugs, and antibacterial agents

LCC Lee, KK Leung, KKW Lo - Dalton Transactions, 2017 - pubs.rsc.org
There has been fast-growing interest in the exploitation of the photophysical and
photochemical properties of luminescent transition metal complexes in biological …