Metals to combat antimicrobial resistance
Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …
New antimicrobial strategies based on metal complexes
M Claudel, JV Schwarte, KM Fromm - Chemistry, 2020 - mdpi.com
Traditional organic antimicrobials mainly act on specific biochemical processes such as
replication, transcription and translation. However, the emergence and wide spread of …
replication, transcription and translation. However, the emergence and wide spread of …
Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains
Daptomycin is a highly efficient last-resort antibiotic that targets the bacterial cell membrane.
Despite its clinical importance, the exact mechanism by which daptomycin kills bacteria is …
Despite its clinical importance, the exact mechanism by which daptomycin kills bacteria is …
N, S, and P-co-doped carbon quantum dots: intrinsic peroxidase activity in a wide pH range and its antibacterial applications
KM Tripathi, HT Ahn, M Chung, XA Le… - ACS Biomaterials …, 2020 - ACS Publications
Nanozymes have drawn significant scientific interest due to their high practical importance in
terms of overcoming the instability, complicated synthesis, and high cost of protein enzymes …
terms of overcoming the instability, complicated synthesis, and high cost of protein enzymes …
Metal complexes, an untapped source of antibiotic potential?
A Frei - Antibiotics, 2020 - mdpi.com
With the widespread rise of antimicrobial resistance, most traditional sources for new drug
compounds have been explored intensively for new classes of antibiotics. Meanwhile, metal …
compounds have been explored intensively for new classes of antibiotics. Meanwhile, metal …
Multitarget approaches against multiresistant superbugs
DA Gray, M Wenzel - ACS Infectious Diseases, 2020 - ACS Publications
Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for
drug discovery to keep pace. Often, resistance against a new drug develops even before it …
drug discovery to keep pace. Often, resistance against a new drug develops even before it …
Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First In Vivo Experiments
There are currently fewer than 10 antifungal drugs in clinical development, but new fungal
strains that are resistant to most current antifungals are spreading rapidly across the world …
strains that are resistant to most current antifungals are spreading rapidly across the world …
Analysis of antimicrobial-triggered membrane depolarization using voltage sensitive dyes
JD Te Winkel, DA Gray, KH Seistrup… - Frontiers in cell and …, 2016 - frontiersin.org
The bacterial cytoplasmic membrane is a major inhibitory target for antimicrobial
compounds. Commonly, although not exclusively, these compounds unfold their …
compounds. Commonly, although not exclusively, these compounds unfold their …
Multi-functional fluorescent carbon dots with antibacterial and gene delivery properties
Glucose is abundant in nature and can be found in various sources. In this study, we
developed multifunctional carbon dots (CDs) with glucose and poly (ethyleneimine)(PEI) …
developed multifunctional carbon dots (CDs) with glucose and poly (ethyleneimine)(PEI) …
Recent development of luminescent rhenium (I) tricarbonyl polypyridine complexes as cellular imaging reagents, anticancer drugs, and antibacterial agents
There has been fast-growing interest in the exploitation of the photophysical and
photochemical properties of luminescent transition metal complexes in biological …
photochemical properties of luminescent transition metal complexes in biological …