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Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists—A perspective
Hypertension is a major risk factor for human morbidity and mortality through its effects on
target organs like heart, brain and kidneys. More intensive treatment for the effective control …
target organs like heart, brain and kidneys. More intensive treatment for the effective control …
Rational drug design and synthesis of molecules targeting the angiotensin II type 1 and type 2 receptors
The angiotensin II (Ang II) type 1 and type 2 receptors (AT1R and AT2R) orchestrate an
array of biological processes that regulate human health. Aberrant function of these …
array of biological processes that regulate human health. Aberrant function of these …
Biocompatible PEO-b-PCL nanosized micelles as drug carriers: Structure and drug–polymer interactions
We report on the preparation of drug nanocarriers by encapsulating losartan potassium
(LSR) into amphiphilic block copolymer micelles, utilizing the biocompatible/biodegradable …
(LSR) into amphiphilic block copolymer micelles, utilizing the biocompatible/biodegradable …
[HTML][HTML] Interactions of the AT1 antagonist valsartan with dipalmitoyl-phosphatidylcholine bilayers
C Potamitis, P Chatzigeorgiou, E Siapi, K Viras… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Valsartan is a marketed drug with high affinity to the type 1 angiotensin (AT1) receptor. It has
been reported that AT1 antagonists may reach the receptor site by diffusion through the …
been reported that AT1 antagonists may reach the receptor site by diffusion through the …
In Silico Drug Screening Approach for the Design of Magic Bullets: A Successful Example with Anti-HIV Fullerene Derivatized Amino Acids
A database has been derived from recently reported [60] fullerene derivatives, and their
binding scores with HIV-1 PR have been computed using docking techniques …
binding scores with HIV-1 PR have been computed using docking techniques …
[HTML][HTML] Poly (2-oxazoline)-based amphiphilic gradient copolymers as nanocarriers for losartan: Insights into drug–polymer interactions
The current study is focused on the development of highly stable drug nanocarriers by
encapsulating losartan potassium (LSR) into an amphiphilic biocompatible poly (2-methyl-2 …
encapsulating losartan potassium (LSR) into an amphiphilic biocompatible poly (2-methyl-2 …
Sulfur centered hydrogen bonding in thioglycolic acid and its clusters: a computational exploration
The conformational landscape of thioglycolic acid (TGA) was investigated by using the
CCSD/cc-pVTZ level of theory. The GGC conformer was identified as the global minimum …
CCSD/cc-pVTZ level of theory. The GGC conformer was identified as the global minimum …
[HTML][HTML] From angiotensin II to cyclic peptides and angiotensin receptor blockers (ARBs): Perspectives of ARBs in COVID-19 therapy
The octapeptide hormone angiotensin II is one of the most studied peptides with the aim of
designing and synthesizing non-peptide mimetics for oral administration. To achieve this …
designing and synthesizing non-peptide mimetics for oral administration. To achieve this …
Losartan's affinity to fluid bilayers modulates lipid–cholesterol interactions
Losartan is an angiotensin II receptor antagonist mainly used for the regulation of high blood
pressure. Since it was anticipated that losartan reaches the receptor site via membrane …
pressure. Since it was anticipated that losartan reaches the receptor site via membrane …
[HTML][HTML] Insights into the molecular basis of action of the AT1 antagonist losartan using a combined NMR spectroscopy and computational approach
The drug: membrane interactions for the antihypertensive AT1 antagonist losartan, the
prototype of the sartans class, are studied herein using an integrated approach. The …
prototype of the sartans class, are studied herein using an integrated approach. The …