The naïve T‐cell repertoire is vast, containing millions of unique T‐cell receptor (TCR)
structures. Faced with such diversity, the mobilization of TCR structures from this enormous …

MULTIPLE sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system in which a restricted cellular immune response has been observed. In order to …

To examine T cell receptor (TCR) diversity involved in the memory response to a persistent
human pathogen, we determined nucleotide sequences encoding TCR-alpha and-beta …

Although HLA class I alleles can bind epitopes up to 14 amino acids in length, little is known
about the immunogenicity or the responding T-cell repertoire against such determinants …

The energetic bases of T cell recognition are unclear. Here, we studied the'energetic
landscape'of peptide–major histocompatibility complex (pMHC) recognition by an …

Two unusual characteristics of the memory response to the immunodominant Epstein-Barr
virus (EBV) epitope FLRGRAYGL, which associates with HLA B8, have provided an unique …

Despite the∼ 1018 αβ T cell receptor (TCR) structures that can be randomly manufactured
by the human thymus, some surface more frequently than others. The pinnacles of this …

Polymyositis is an inflammatory myopathy characterized by mononuclear cell infiltration of
muscle tissue. Myocytotoxic T lymphocytes have been recognized in the infiltrates, but the …

MHC class I molecules generally present peptides of 8–10 aa long, forming an extended coil
in the HLA cleft. Although longer peptides can also bind to class I molecules, they tend to …

Inclusion body myositis (IBM) is an inflammatory myopathy characterized
immunohistologically by prominent invasion of the non-necrotic, MHC-I class antigen …