Cells rely on surveillance systems such as autophagy to handle protein alterations and
organelle damage. Dysfunctional autophagy, an evolutionarily conserved cellular …

Parkinson disease (PD) is known as a common progressive neurodegenerative disease
which is clinically diagnosed by the manifestation of numerous motor and nonmotor …

Mitochondrial quality control, which is crucial for maintaining cellular homeostasis, has been
considered to be achieved exclusively through mitophagy. Here we report an alternative …

Neuroinflammation and mitochondrial dysfunction, key mechanisms in the pathogenesis of
Parkinson's disease (PD), are usually explored independently. Loss‐of‐function mutations …

Background Mutations in PINK1 and parkin cause autosomal recessive Parkinson's disease
(PD). Evidence placing PINK1 and parkin in common pathways regulating multiple aspects …

Mutations in PARK2, encoding the E3 ubiquitin protein ligase Parkin, are a common cause
of autosomal recessive Parkinson's disease (PD). Loss of PARK2 function compromises …

Mutations and loss of activity in PARKIN, an E3 ubiquitin ligase, play a role in the
pathogenesis of Parkinson's disease (PD). PARKIN regulates many aspects of mitochondrial …

Parkinson's disease patients report disturbed sleep patterns long before motor dysfunction.
Here, in parkin and pink1 models, we identify circadian rhythm and sleep pattern defects …

The mechanisms by which parkin protects the adult human brain from Parkinson disease
remain incompletely understood. We hypothesized that parkin cysteines participate in redox …

Autophagy is a major regulatory cellular mechanism which gives the cell an ability to cope
with some of the destructive events that normally occur within a metabolically living cell. This …