Over the past two decades, research has identified extrasynaptic GABA A receptor
populations that enable neurons to sense the low ambient GABA concentrations present in …

Neuroactive steroids such as allopregnanolone do not only act as transcriptional factors in
the regulation of gene expression after intracellular back-oxidation into the 5-α pregnane …

Like other classes of treatments described in this issue's section, neuroactive steroids have
been studied for decades but have risen as a new class of rapid-acting, durable …

Rationale Neurosteroids are steroids synthesized within the brain with rapid effects on
neuronal excitability. Allopregnanolone, allotetrahydrodeoxycorticosterone, and …

Post‐traumatic stress disorder (PTSD) and alcohol‐use disorder (AUD) are highly comorbid
in humans. Although we have some understanding of the structural and functional brain …

Stress and previous adverse life events are well-established risk factors for depression.
Further, neuroendocrine disruptions are associated with both major depressive disorder …

By rapidly modulating neuronal excitability, neurosteroids regulate physiological processes,
such as responses to stress and development. Excessive stress affects their biosynthesis …

The most commonly reported precipitating factor for seizures is stress. However, the
underlying mechanisms whereby stress triggers seizures are not yet fully understood. Here …

Premenstrual dysphoric disorder (PMDD) is characterized by the predictable onset of mood
and physical symptoms secondary to gonadal steroid fluctuation during the luteal phase of …

This review highlights early efforts to translate pre-clinical and clinical findings regarding the
role of neuroactive steroids in stress adaptation and PTSD into new therapeutics for PTSD …