Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid
hormone and their structural and functional analysis revealed an evolutionarily conserved …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Zygotic genome activation (ZGA) marks the beginning of the embryonic program for a
totipotent embryo, which gives rise to the inner cell mass (ICM) where pluripotent epiblast …

The circadian clock and associated feeding rhythms have a profound impact on metabolism
and the gut microbiome. To what extent microbiota reciprocally affect daily rhythms of …

Growing evidence suggests that close appositions between the endoplasmic reticulum (ER)
and other membranes, including appositions with the plasma membrane (PM), mediate …

Nuclear receptor pharmacology has, to a certain extent, led the way, compared with other
receptor systems, in the appreciation that ligands may exert very diverse pharmacology …

The nuclear receptor PPARα is activated by drugs to treat human disorders of lipid
metabolism. Its endogenous ligand is unknown. PPARα-dependent gene expression is …

Steroids play an important role in the regulation of normal physiology and the treatment of
disease. Steroid receptors have classically been described as ligand-activated transcription …

Nuclear receptors are ancient ligand-regulated transcription factors that control key
metabolic and developmental pathways. The fruitfly Drosophila melanogaster has only 18 …

Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with
classic nuclear receptor domain structure lacking identified signaling ligands are designated …