Poly (A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called
cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has …

Oocyte developmental competence is the ability of the mature oocyte to be fertilized and
subsequently drive early embryo development. Developmental competence is acquired by …

Oocyte maturation, fertilization, and early embryonic development occur in the absence of
gene transcription. Therefore, it is critical to understand at a global level the post …

Hematopoietic stem cells (HSCs) are maintained through the regulation of symmetric and
asymmetric cell division. We report that conditional ablation of the RNA-binding protein Msi2 …

Eggs accumulate thousands of translationally repressed mRNAs that are translated into
proteins after fertilization to direct diverse developmental processes. However, molecular …

Translational control of specific mRNAs is a widespread mechanism of gene regulation, and
it is especially important in pattern formation in the oocytes of organisms in which the …

The Musashi proteins, MSI1 and MSI2, are conserved RNA binding proteins with a role in
the maintenance and renewal of stem cells. Contrasting with this role, terminally …

Cytoplasmic polyadenylation is the process by which dormant, translationally inactive
mRNAs become activated via the elongation of their poly (A) tails in the cytoplasm. This …

The pituitary functions as a master endocrine gland that secretes hormones critical for
regulation of a wide variety of physiological processes including reproduction, growth …

Translational regulation contributes to the control of archetypal and specialized cell cycles,
such as the meiotic and early embryonic cycles. Late meiosis and early embryogenesis …