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Cuproptosis: harnessing transition metal for cancer therapy
Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …
Biomaterials elicit pyroptosis enhancing cancer immunotherapy
MJ Zhang, YY Wang, LL Han, XY Liu… - Advanced Functional …, 2024 - Wiley Online Library
Cancer immunotherapy has the potential to revolutionize the treatment of malignant tumors,
but its effectiveness is limited by the low immune response rate and immune‐related …
but its effectiveness is limited by the low immune response rate and immune‐related …
Self‐destructive copper carriers induce pyroptosis and cuproptosis for efficient tumor immunotherapy against dormant and recurrent tumors
L Qiao, G Zhu, T Jiang, Y Qian, Q Sun… - Advanced …, 2024 - Wiley Online Library
Activating the strong immune system is a key initiative to counteract dormant tumors and
prevent recurrence. Herein, self‐destructive and multienzymatically active copper‐quinone …
prevent recurrence. Herein, self‐destructive and multienzymatically active copper‐quinone …
Photocatalytic carbon dots‐triggered pyroptosis for whole cancer cell vaccines
Manufacturing whole cancer cell vaccines (WCCV) with both biosafety and efficacy is crucial
for tumor immunotherapy. Pyroptotic cancer cells, due to their highly immunogenic …
for tumor immunotherapy. Pyroptotic cancer cells, due to their highly immunogenic …
Multifunctional Copper‐Phenolic Nanopills Achieve Comprehensive Polyamines Depletion to Provoke Enhanced Pyroptosis and Cuproptosis for Cancer …
G Zhu, Y **e, J Wang, M Wang, Y Qian… - Advanced …, 2024 - Wiley Online Library
The overexpression of polyamines in tumor cells contributes to the establishment of
immunosuppressive microenvironment and facilitates tumor growth. Here, it have …
immunosuppressive microenvironment and facilitates tumor growth. Here, it have …
Lysosomal rupture‐mediated “broken window effect” to amplify cuproptosis and pyroptosis for high‐efficiency cancer immunotherapy
G Zhu, M Wang, L Qiao, Y **e, J Wang… - Advanced Functional …, 2024 - Wiley Online Library
Autophagy, a lysosome‐involved degradation pathway, as a self‐protective cellular process,
always weakens the efficiency of tumor therapies. Herein, for the first time, the …
always weakens the efficiency of tumor therapies. Herein, for the first time, the …
Multifunctional Au@AgBiS2 Nanoparticles as High‐Efficiency Radiosensitizers to Induce Pyroptosis for Cancer Radioimmunotherapy
L **ao, B Chen, W Wang, T Tian, H Qian… - Advanced …, 2023 - Wiley Online Library
Radiotherapy (RT), a widely used clinical treatment modality for cancer, uses high‐energy
irradiation for reactive oxygen species (ROS) production and DNA damage. However, its …
irradiation for reactive oxygen species (ROS) production and DNA damage. However, its …
A multifunctional covalent organic framework nanozyme for promoting ferroptotic radiotherapy against esophageal cancer
LL Zhou, Q Guan, W Zhou, JL Kan, K Teng, M Hu… - ACS …, 2023 - ACS Publications
Radiotherapy is inevitably accompanied by some degree of radiation resistance, which
leads to local recurrence and even therapeutic failure. To overcome this limitation, herein …
leads to local recurrence and even therapeutic failure. To overcome this limitation, herein …
Hypoxia-accelerating pyroptosis nanoinducers for promoting image-guided cancer immunotherapy
D Liu, M Liang, Y Tao, H Liu, Q Liu, W Bing, W Li, J Qi - Biomaterials, 2024 - Elsevier
Precise image-guided cancer immunotherapy holds immense potential in revolutionizing
cancer treatment. The strategies facilitating activatable imaging and controlled therapeutics …
cancer treatment. The strategies facilitating activatable imaging and controlled therapeutics …
Recent advances in the metal/organic hybrid nanomaterials for cancer theranostics
Z Ye, Y Bao, Z Chen, H Ye, Z Feng, Y Li, Y Zeng… - Coordination Chemistry …, 2024 - Elsevier
Cancer is an extremely significant disease that profoundly impacts human survival and
quality of life. Researchers have been searching for effective therapies, among which …
quality of life. Researchers have been searching for effective therapies, among which …