Cuproptosis: harnessing transition metal for cancer therapy

W Wang, W Mo, Z Hang, Y Huang, H Yi, Z Sun, A Lei - ACS nano, 2023 - ACS Publications
Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

Biomaterials elicit pyroptosis enhancing cancer immunotherapy

MJ Zhang, YY Wang, LL Han, XY Liu… - Advanced Functional …, 2024 - Wiley Online Library
Cancer immunotherapy has the potential to revolutionize the treatment of malignant tumors,
but its effectiveness is limited by the low immune response rate and immune‐related …

Self‐destructive copper carriers induce pyroptosis and cuproptosis for efficient tumor immunotherapy against dormant and recurrent tumors

L Qiao, G Zhu, T Jiang, Y Qian, Q Sun… - Advanced …, 2024 - Wiley Online Library
Activating the strong immune system is a key initiative to counteract dormant tumors and
prevent recurrence. Herein, self‐destructive and multienzymatically active copper‐quinone …

Photocatalytic carbon dots‐triggered pyroptosis for whole cancer cell vaccines

Q Cheng, T Zhang, Q Wang, X Wu, L Li… - Advanced …, 2024 - Wiley Online Library
Manufacturing whole cancer cell vaccines (WCCV) with both biosafety and efficacy is crucial
for tumor immunotherapy. Pyroptotic cancer cells, due to their highly immunogenic …

Multifunctional Copper‐Phenolic Nanopills Achieve Comprehensive Polyamines Depletion to Provoke Enhanced Pyroptosis and Cuproptosis for Cancer …

G Zhu, Y **e, J Wang, M Wang, Y Qian… - Advanced …, 2024 - Wiley Online Library
The overexpression of polyamines in tumor cells contributes to the establishment of
immunosuppressive microenvironment and facilitates tumor growth. Here, it have …

Lysosomal rupture‐mediated “broken window effect” to amplify cuproptosis and pyroptosis for high‐efficiency cancer immunotherapy

G Zhu, M Wang, L Qiao, Y **e, J Wang… - Advanced Functional …, 2024 - Wiley Online Library
Autophagy, a lysosome‐involved degradation pathway, as a self‐protective cellular process,
always weakens the efficiency of tumor therapies. Herein, for the first time, the …

Multifunctional Au@AgBiS2 Nanoparticles as High‐Efficiency Radiosensitizers to Induce Pyroptosis for Cancer Radioimmunotherapy

L **ao, B Chen, W Wang, T Tian, H Qian… - Advanced …, 2023 - Wiley Online Library
Radiotherapy (RT), a widely used clinical treatment modality for cancer, uses high‐energy
irradiation for reactive oxygen species (ROS) production and DNA damage. However, its …

A multifunctional covalent organic framework nanozyme for promoting ferroptotic radiotherapy against esophageal cancer

LL Zhou, Q Guan, W Zhou, JL Kan, K Teng, M Hu… - ACS …, 2023 - ACS Publications
Radiotherapy is inevitably accompanied by some degree of radiation resistance, which
leads to local recurrence and even therapeutic failure. To overcome this limitation, herein …

Hypoxia-accelerating pyroptosis nanoinducers for promoting image-guided cancer immunotherapy

D Liu, M Liang, Y Tao, H Liu, Q Liu, W Bing, W Li, J Qi - Biomaterials, 2024 - Elsevier
Precise image-guided cancer immunotherapy holds immense potential in revolutionizing
cancer treatment. The strategies facilitating activatable imaging and controlled therapeutics …

Recent advances in the metal/organic hybrid nanomaterials for cancer theranostics

Z Ye, Y Bao, Z Chen, H Ye, Z Feng, Y Li, Y Zeng… - Coordination Chemistry …, 2024 - Elsevier
Cancer is an extremely significant disease that profoundly impacts human survival and
quality of life. Researchers have been searching for effective therapies, among which …