1.2. Definitions Ulcerative colitis [UC] is a chronic inflammatory condition that causes
continuous mucosal inflammation of the colon, usually without granulomas on biopsy. It …

Autoimmune diseases are a range of diseases in which the immune response to self-
antigens results in damage or dysfunction of tissues. Autoimmune diseases can be systemic …

Ulcerative colitis is a lifelong disease arising from an interaction between genetic and
environmental factors, observed predominantly in the developed countries of the world. The …

Research over the last few years has revealed significant haplotype structure in the human
genome. The characterization of these patterns, particularly in the context of medical genetic …

Background The molecular cause of inflammatory bowel disease is largely unknown.
Methods We performed genetic-linkage analysis and candidate-gene sequencing on …

Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel disorders. In this
paper, we discuss how environmental factors (eg, geography, cigarette smoking, sanitation …

The gut mucosa is constantly challenged by a bombardment of foreign antigens and
environmental microorganisms. As such, the precise regulation of the intestinal barrier …

Genetic factors strongly affect susceptibility to common diseases and also influence disease-
related quantitative traits. Identifying the relevant genes has been difficult, in part because …

Crohn's disease and ulcerative colitis are idiopathic, chronic, relapsing, inflammatory
conditions that are immunologically mediated. Although their exact etiologies remain …

We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735
individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were …