The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

The use of high-throughput next-generation sequencing techniques in multiple tumor types
during the last few years has identified NTRK1, 2, and 3 gene rearrangements encoding …

Within the gastrointestinal stem cell niche, nerves help to regulate both normal and
neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer …

Studies have reported the vital role of nerves in tumorigenesis and cancer progression.
Nerves infiltrate the tumor microenvironment thereby enhancing cancer growth and …

Ongoing and breakthrough pain is a primary concern for the cancer patient. Although the
etiology of cancer pain remains unclear, animal models of cancer pain have allowed …

Introduction Breast cancer is a complex heterogeneous disease and is a leading cause of
death in women. Early diagnosis and monitoring progression of breast cancer are important …

Nerve growth factor (NGF), a neurotrophin that plays a crucial role in promoting neurotrophic
and neurotropic effects in sympathetic neurons, has recently been identified as a novel …

Neuroblastoma (NB) is one of the most common and deadly childhood solid tumors. These
tumors are characterized by clinical heterogeneity, from spontaneous regression to …

By screening a tissue microarray of invasive breast tumors, we have shown that the receptor
tyrosine kinase RET (REarranged during Transfection) and its coreceptor GFRα1 (GDNF …

The regulation of the immune environment within the tumor microenvironment has provided
new opportunities for cancer treatment. However, an important microenvironment …