Epistasis occurs when the effect of a mutation depends on its carrier's genetic background.
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …

Mutation accumulation (MA) experiments, in which mutations are allowed to drift to fixation in
inbred lines, have been a principal way of studying the rates and properties of new …

Predictions based on evolutionary theory suggest that the adaptive value of evolved
herbicide resistance alleles may be compromised by the existence of fitness costs. There …

Viruses are common agents of plant infectious diseases. During last decades, worldwide
agriculture production has been compromised by a series of epidemics caused by new …

An increasing number of studies demonstrate phenotypic and genetic changes in natural
populations that are subject to climate change, and there is hope that some of these …

The accumulation of data on the genomic bases of adaptation has triggered renewed
interest in theoretical models of adaptation. Among these models, Fisher's geometric model …

Many multicellular eukaryotes have reasonably high per-generation mutation rates.
Consequently, most populations harbor an abundance of segregating deleterious alleles …

Climate change is imposing intensified and novel selection pressures on organisms by
altering abiotic and biotic environmental conditions on Earth, but studies demonstrating …

Adaptation often proceeds from standing variation, and natural selection acting on pairs of
populations is a quantitative continuum ranging from parallel to divergent. Yet, it is unclear …

How do the fitness effects of several mutations combine? Despite its simplicity, this question
is central to the understanding of multilocus evolution. Epistasis (the interaction between …