[HTML][HTML] Mitochondria as central hub of the immune system
Nearly 130 years after the first insights into the existence of mitochondria, new
rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell …
rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell …
Tau in Alzheimer's disease: mechanisms and therapeutic strategies
Y Gao, L Tan, JT Yu, L Tan - Current Alzheimer Research, 2018 - ingentaconnect.com
Objective: Alzheimer's disease (AD), the most important progressive neurodegenerative
disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a …
disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a …
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation
Oligomerization of tau is a key process contributing to the progressive death of neurons in
Alzheimer's disease. Tau is modified by O-linked N-acetylglucosamine (O-GlcNAc), and O …
Alzheimer's disease. Tau is modified by O-linked N-acetylglucosamine (O-GlcNAc), and O …
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease
O-GlcNAcylation is the addition of β-DN-acetylglucosamine to serine or threonine residues
of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not …
of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not …
Analytical and biochemical perspectives of protein O-GlcNAcylation
Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …
unique monosaccharide modification discovered in the early 1980s. With the technological …
O-GlcNAc Cycling: A Link Between Metabolism and Chronic Disease
MR Bond, JA Hanover - Annual review of nutrition, 2013 - annualreviews.org
To maintain homeostasis under variable nutrient conditions, cells rapidly and robustly
respond to fluctuations through adaptable signaling networks. Evidence suggests that the O …
respond to fluctuations through adaptable signaling networks. Evidence suggests that the O …
O-GlcNAcylation: A New Cancer Hallmark?
O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a reversible post-translational
modification consisting in the addition of a sugar moiety to serine/threonine residues of …
modification consisting in the addition of a sugar moiety to serine/threonine residues of …
An overview of glycosylation and its impact on cardiovascular health and disease
KJ Loaeza-Reyes, E Zenteno… - Frontiers in molecular …, 2021 - frontiersin.org
The cardiovascular system is a complex and well-organized system in which glycosylation
plays a vital role. The heart and vascular wall cells are constituted by an array of specific …
plays a vital role. The heart and vascular wall cells are constituted by an array of specific …
Human Serum/Plasma Glycoprotein Analysis by 1H-NMR, an Emerging Method of Inflammatory Assessment
Several studies suggest that variations in the concentration of plasma glycoproteins can
influence cellular changes in a large number of diseases. In recent years, proton nuclear …
influence cellular changes in a large number of diseases. In recent years, proton nuclear …
O-GlcNAc modification, insulin signaling and diabetic complications
T Issad, E Masson, P Pagesy - Diabetes & metabolism, 2010 - Elsevier
O-GlcNAc glycosylation (O-GlcNAcylation) corresponds to the addition of N-
acetylglucosamine on serine and threonine residues of cytosolic and nuclear proteins. O …
acetylglucosamine on serine and threonine residues of cytosolic and nuclear proteins. O …