Background: Hypertrophic cardiomyopathy (HCM) is caused by pathogenic variants in
sarcomere protein genes that evoke hypercontractility, poor relaxation, and increased …

Many lines of evidence suggest that mitochondria have a central role in aging-related
neurodegenerative diseases, such as Alzheimer's disease (AD). Mitochondrial dysfunction …

Abstract Purpose of Review Left ventricular hypertrophy (LVH) is a common presentation
encountered in clinical practice with a diverse range of potential aetiologies. Differentiation …

Background: Defects in energetics are thought to be central to the pathophysiology of
hypertrophic cardiomyopathy (HCM); yet, the determinants of ATP availability are not known …

Duchenne muscular dystrophy (DMD) is a progressive skeletal muscle disease that is
associated with severe cardiac complications in the late stages. Significant mitochondrial …

Cardiac mechanical function is supported by ATP hydrolysis, which provides the chemical-
free energy to drive the molecular processes underlying cardiac pum**. Physiological …

Background and Objectives: The heart is the organ with the highest metabolic demand in the
body, and it relies on high ATP turnover and efficient energy substrate utilisation in order to …

Purine nucleotides play central roles in energy metabolism in the heart. Most fundamentally,
the free energy of hydrolysis of the adenine nucleotide adenosine triphosphate (ATP) …

A three‐dimensional (3D), density‐weighted, concentric rings trajectory (CRT) magnetic
resonance spectroscopic imaging (MRSI) sequence is implemented for cardiac phosphorus …

Introduction Mitochondrial dysfunction is a neurometabolic hallmark signaling abnormal
brain energy metabolism (BEM) targeted as a potential early marker of Alzheimer's disease …