Function and molecular mechanism of the DNA damage response in immunity and cancer immunotherapy
The DNA damage response (DDR) is an organized network of multiple interwoven
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …
RecBCD enzyme: mechanistic insights from mutants of a complex helicase-nuclease
SK Amundsen, GR Smith - Microbiology and Molecular Biology …, 2023 - Am Soc Microbiol
RecBCD enzyme is a multi-functional protein that initiates the major pathway of homologous
genetic recombination and DNA double-strand break repair in Escherichia coli. It is also …
genetic recombination and DNA double-strand break repair in Escherichia coli. It is also …
[PDF][PDF] Putting AlphaFold models to work with phenix. process_predicted_model and ISOLDE
AlphaFold has recently become an important tool in providing models for experimental
structure determination by X-ray crystallography and cryo-EM. Large parts of the predicted …
structure determination by X-ray crystallography and cryo-EM. Large parts of the predicted …
Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites
Common fragile sites (CFSs) are difficult-to-replicate genomic regions that form gaps and
breaks on metaphase chromosomes under replication stress. They are hotspots for …
breaks on metaphase chromosomes under replication stress. They are hotspots for …
Targeting ATR in patients with cancer
Pharmacological inhibition of the ataxia telangiectasia and Rad3-related protein
serine/threonine kinase (ATR; also known as FRAP-related protein (FRP1)) has emerged as …
serine/threonine kinase (ATR; also known as FRAP-related protein (FRP1)) has emerged as …
GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer
Growth factor receptor-bound protein 2 (GRB2) is a cytoplasmic adapter for tyrosine kinase
signaling and a nuclear adapter for homology-directed-DNA repair. Here we find nuclear …
signaling and a nuclear adapter for homology-directed-DNA repair. Here we find nuclear …
Repair and tolerance of DNA damage at the replication fork: A structural perspective
BF Eichman - Current Opinion in Structural Biology, 2023 - Elsevier
The replication machinery frequently encounters DNA damage and other structural
impediments that inhibit progression of the replication fork. Replication-coupled processes …
impediments that inhibit progression of the replication fork. Replication-coupled processes …
CK2-dependent degradation of CBX3 dictates replication fork stalling and PARP inhibitor sensitivity
J Ma, D Ren, Z Wang, W Li, L Li, T Liu, Q Ye, Y Lei… - Science …, 2024 - science.org
DNA replication is a vulnerable cellular process, and its deregulation leads to genomic
instability. Here, we demonstrate that chromobox protein homolog 3 (CBX3) binds …
instability. Here, we demonstrate that chromobox protein homolog 3 (CBX3) binds …
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important …
Characterizing the molecular deficiencies underlying human aging has been a formidable
challenge as it is clear that a complex myriad of factors including genetic mutations …
challenge as it is clear that a complex myriad of factors including genetic mutations …
PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells
K Yano, M Kato, S Endo, T Igarashi, R Wada… - Cell Death …, 2025 - nature.com
DNA replication stress (RS), a prevalent feature of various malignancies, arises from both
genetic mutations and genotoxic exposure. Elevated RS levels increase the vulnerability of …
genetic mutations and genotoxic exposure. Elevated RS levels increase the vulnerability of …