The collaborative study on the genetics of alcoholism (COGA) is a multi‐site,
multidisciplinary project with the goal of identifying how genes are involved in alcohol use …

Lifetime and temporal co-occurrence of substance use disorders (SUDs) is common and
compared with individual SUDs is characterized by greater severity, additional psychiatric …

Introduction: Population-level substance use research primarily relies on self-reports, which
often underestimate actual use. Hair analyses offer a more objective estimate; however …

Substance use disorders (SUDs) are highly prevalent and associated with excess morbidity,
mortality, and economic costs. Thus, there is considerable interest in the early identification …

Abstract Alcohol Use Disorder is a complex genetic disorder, involving genetic, neural, and
environmental factors, and their interactions. The Collaborative Study on the Genetics of …

Alcohol use disorders (AUD) are complex traits that are moderately heritable. A variety of
approaches have been developed that allow researchers to better understand their genetic …

Introduction Early mid-life is marked by accumulating risks for cardiometabolic illness linked
to health-risk behaviors like nicotine use. Identifying polygenic indices (PGI) has enriched …

Although genome-wide association studies (GWAS) have identified loci associated with
alcohol consumption and alcohol use disorder (AUD), they do not identify which variants are …

Importance Many psychiatric outcomes share a common etiologic pathway reflecting
behavioral disinhibition, generally referred to as externalizing (EXT) disorders. Recent …

Substance use and substance use disorders run in families. While it has long been
recognized that the etiology of substance use behaviors and disorders involves a …