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Inflammation, Aging, and Cardiovascular Disease: JACC Review Topic of the Week
Aging and inflammation both contribute pivotally to cardiovascular (CV) and cerebrovascular
disease, the leading causes of death and disability worldwide. The concept of inflamm-aging …
disease, the leading causes of death and disability worldwide. The concept of inflamm-aging …
Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society
JE Roeters van Lennep, LS Tokgözoğlu… - European heart …, 2023 - academic.oup.com
Cardiovascular disease is the leading cause of death in women and men globally, with most
due to atherosclerotic cardiovascular disease (ASCVD). Despite progress during the last 30 …
due to atherosclerotic cardiovascular disease (ASCVD). Despite progress during the last 30 …
Pregnancy and reproductive risk factors for cardiovascular disease in women
Beyond conventional risk factors for cardiovascular disease, women face an additional
burden of sex-specific risk factors. Key stages of a woman's reproductive history may …
burden of sex-specific risk factors. Key stages of a woman's reproductive history may …
Clonal haematopoiesis and dysregulation of the immune system
Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …
Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease
Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …
Association of clonal hematopoiesis with incident heart failure
Background Age-related clonal hematopoiesis of indeterminate potential (CHIP), defined as
clonally expanded leukemogenic sequence variations (particularly in DNMT3A, TET2 …
clonally expanded leukemogenic sequence variations (particularly in DNMT3A, TET2 …
Cognitive decline in early and premature menopause
Early and premature menopause, or premature ovarian insufficiency (POI), affects 1% of
women under the age of 40 years. This paper reviews the main aspects of early and …
women under the age of 40 years. This paper reviews the main aspects of early and …
Clonal hematopoiesis of indeterminate potential predicts adverse outcomes in patients with atherosclerotic cardiovascular disease
Background Clonal hematopoiesis of indeterminate potential (CHIP)—the age-related clonal
expansion of blood stem cells with leukemia-associated mutations—is a novel …
expansion of blood stem cells with leukemia-associated mutations—is a novel …
Clonal hematopoiesis: Mutation-specific adaptation to environmental change
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …
of genetically variant hematopoietic cells that increases exponentially with age and is …
Unidirectional association of clonal hematopoiesis with atherosclerosis development
Clonal hematopoiesis, a condition in which acquired somatic mutations in hematopoietic
stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher …
stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher …