Fracture risk is increased in patients with type 2 diabetes mellitus (T2DM). In addition, these
patients sustain fractures despite having higher levels of areal bone mineral density, as …

Diabetes is a highly prevalent disease with complications that impact most bodily systems.
However, the impact of diabetes on bone health is frequently ignored or underestimated …

The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide, especially as a
result of our aging society, high caloric intake and sedentary lifestyle. Besides the well …

Context: Skeletal deterioration, leading to an increased risk of fracture, is a known
complication of type 2 diabetes mellitus (T2D). Yet plausible mechanisms to account for …

It is well known that bone loss accompanies aging in both men and women and contributes
to skeletal fragility in the older population, but changes that occur to the bone tissue matrix …

Context Increased bone fragility and reduced energy absorption to fracture associated with
type 2 diabetes (T2D) cannot be explained by bone mineral density alone. This study, for the …

Background Type 1 diabetes is associated with lower bone mineral density (BMD) and
increased fracture risk, but little is known regarding the effects of diabetes-related factors on …

Abstract Purpose of Review While thinning of the cortices or trabeculae weakens bone, age-
related changes in matrix composition also lower fracture resistance. This review …

Bone volume, microstructure and its material composition are maintained by bone
remodelling, a cellular activity carried out by bone multicellular units (BMUs). BMUs are …

The accumulation of advanced glycation end-products (AGEs) in the organic matrix of bone
with aging and chronic disease such as diabetes is thought to increase fracture risk …